GAMBARAN POTENSI INTERAKSI OBAT PADA PASIEN SKIZOFRENIA DI RUMAH SAKIT UMUM SIAGA MEDIKA PURBALINGGA

Anwar Rosyadi; Muhamad Jaenal Arifin; Kresensia Stasiana Yunarti

doi:10.33759/v7i3.748

Authors

Anwar Rosyadi STIKes Bina Cipta Husada
Muhamad Jaenal Arifin STIKes Bina Cipta Husada
Kresensia Stasiana Yunarti STIKes Bina Cipta Husada

DOI:

https://doi.org/10.33759/v7i3.748

Keywords:

Interaksi Obat, Pola Penggunaan Obat, Skizofrenia

Abstract

Schizophrenia is a global mental health issue, with relapse often triggered by patient non-adherence to medication. The use of complex drug combinations risks causing drug interactions. Therefore, this study aimed to identify medication use patterns and potential drug interactions in outpatient schizophrenia patients at RSU Siaga Medika Purbalingga. This descriptive research utilized medical records and patient prescriptions from January to June 2024, with samples selected through purposive sampling. Drug interaction analysis was performed using Medscape and Drugs.com applications. The results show that potential drug interactions were categorized as major (15.28%), moderate (79.17%), and minor (72.73%). The most frequent major interaction was found in the combination of Clozapine and Risperidone (16.67%), which can lead to serious side effects such as cardiovascular issues, neuroleptic malignant syndrome, and prolonged QT interval.

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References

Amelia Agustin, O., Farmasi, J., Jambi, U., & Jambi, K. (2020). Kajian Interaksi Obat Berdasarkan Kategori Signifikasi Klinis Terhadap Pola Peresepan Pasien Rawat Jalan di Apotek X Jambi.

Cahyani, G. G. A., & Pratiwi, A. (2023). Beberapa Faktor yang Menyebabkan Kekambuhan Pasien Gangguan Jiwa. Malahayati Nursing Journal, 5(12), 4143–4152. https://doi.org/10.33024/mnj.v5i12.10129

Correll, C. U., Rubio, J. M., & Kane, J. M. (2018). What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia? World Psychiatry, 17(2), 149–160. https://doi.org/10.1002/wps.20516

Dewi, C., & Pasaribu, J. (1984). Strategi Koping Dan Kualitas Hidup Penderita Skizofrenia (Vol. 4, Issue 1).

Divac, N., Prostran, M., Jakovcevski, I., & Cerovac, N. (2019). Second-generation antipsychotics and extrapyramidal adverse effects. In BioMed Research International (Vol. 2014). Hindawi Publishing Corporation. https://doi.org/10.1155/2014/656370

Effendi, L., Darwis, R. S., & Apsari, N. C. (2020). Potret Mantan Pendertita Skizofrenia Ditinjau Dari Strength Perspective. Share : Social Work Journal, 10(1), 51. https://doi.org/10.24198/share.v10i1.26896

Fitria Wahyuning Wulan, & Wenni Arina Dewi. (2024). Analisis Kejadian Interaksi Obat pada Pasien Skizofrenia di RSUD Dr. Iskak Tulungagung. Jurnal Medika Nusantara, 2(1), 229–237. https://doi.org/10.59680/medika.v2i1.922

Galling, B., Roldán, A., Hagi, K., Rietschel, L., Walyzada, F., Zheng, W., Cao, X. L., Xiang, Y. T., Zink, M., Kane, J. M., Nielsen, J., Leucht, S., & Correll, C. U. (2017). Antipsychotic augmentation vs. monotherapy in schizophrenia: systematic review, meta-analysis and meta-regression analysis. World Psychiatry, 16(1), 77–89. https://doi.org/10.1002/wps.20387

Glennasius, T., & Ernawati, E. (2023). Program Intervensi Dalam Upaya Peningkatan Pengetahuan dan Keteraturan Berobat Pasien Skizofrenia di Wilayah Kerja Puskesmas Sindang Jaya. Malahayati Nursing Journal, 5(12), 4239–4249. https://doi.org/10.33024/mnj.v5i12.12528

Hafifah, A., Puspitasari, I.M., Sinuraya, R.K., (2018). Studi Pemberian Antipsikotik Terhadap Beberapa Jenis Skizofrenia. Farmaka Suplemen, 16(2), 210-232.

Jannah, K. M., Dania, H., & Faridah, I. N. (2021). Hubungan Jumlah Obat dengan Potensial Kejadian Interaksi Obat pada Pasien Skizofrenia di Salah Satu Rumah Sakit di Kulon Progo, Yogyakarta The Correlation of Drug Quantity with the Potential Drug Interaction Occurrences on Schizophrenic Patients in One of The Hospitals in Kulon Progo, Yogyakarta. In Pharmaceutical Journal of Indonesia (Vol. 18, Issue 02). www.medscape.com

Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., Samara, M., Barbui, C., Engel, R. R., Geddes, J. R., Kissling, W., Stapf, M. P., Lässig, B., Salanti, G., & Davis, J. M. (2020). Comparative Efficacy and Tolerability of 15 Antipsychotic Drugs in Schizophrenia: A Multiple-Treatments Meta-Analysis: Vol. XII (Issue 2).

NICE (National Institute for Health and Care Excellence). (2014). Psychosis and Schizophrenia in Adults: Prevention and Management. NICE Guideline CG178.

Novitayani, S. (2016). Characteristic of Schizophrenic Patient with Experience Rehospitalization. Idea Nursing Journal. Vol. VII No. 2. hal. 23-29.

Putri, T. H., & Agustia, Y. (n.d.). Faktor Karakteristik dalam Kejadian Kekambuhan pada Pasien Skizofrenia Characteristic Factors Affecting Relapse of Schizophrenia Patients. In Jurnal Kesehatan (Vol. 13, Issue 1). Online. http://ejurnal.poltekkes-tjk.ac.id/index.php/JK

Ramadia, A., Rahmat Aziz, A., & Eri, M. (2022). Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Kontrol Berobat Orang Dengan Gangguan Jiwa. JKJ): Persatuan Perawat Nasional Indonesia, 10.

Siregar, MP. (2008). Gangguan Psikiatrik. BUKU ACUAN Modul GANGGUAN PSIKIATRIK. hal 1-116.

Subagyo, R., Prasetya, E. C., Hamida, A., Rafida, M., Ramzi, M. ., Nugraha, M. T., Haniifah, U., & Anas, M. (2022). Laporan Kasus: Skizofrenia Paranoid. Journal of Islamic Medicine, 6(02), 113–118. https://doi.org/10.18860/jim.v6i2.17456

Tiihonen, J., Mittendorfer-Rutz, E., Torniainen, M., Alexanderson, K., & Tanskanen, A. (2016). Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: An observational follow-up study. American Journal of Psychiatry, 173(6), 600–606. https://doi.org/10.1176/appi.ajp.2015.15050618

Utami, V. W., Darajati, M., & Puspitasari, C. E. (2022). Potensi interaksi obat pada pasien skizofrenia di Rumah Sakit Jiwa Mutiara Sukma tahun 2020. Sasambo Journal of Pharmacy, 3(1), 36–42. https://doi.org/10.29303/sjp.v3i1.151

Zulkifli, A. & Febriyana, N. (2017). Efek Penggunaan Obat Antikolinergik Pada Pasien Skizofrenia. Jurnal Psikiatri Surabaya. Vol. 59-67. 6 No. 2. hal https://doi.org/10.20473/jps.v6i2.19428