POLA PENGGUNAAN DAN ANALISIS EFEKTIVITAS BIAYA OBAT ANTINYERI PADA PASIEN DIABETIK NEUROPATI DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG

Authors

  • Tri Purma Sari Magister Farmasi Klinik Fakultas Farmasi Universitas Ahmad Dahlan
  • Dyah Aryani Perwitasari Universitas Ahmad Dahlan
  • Woro Supadmi Universitas Ahmad Dahlan

DOI:

https://doi.org/10.33759/jrki.v5i3.390

Keywords:

Diabetik Neuropati, Obat Antinyeri, Analisis Efektivitas Biaya

Abstract

Diabetic neuropathy is gathering symptom clinic which influence system nerves, well single or combination and could happen in a manner suddenly, no detected, with symptom clinic and no specific signs but dangerous. Incidence diabetic neuropathy happen between 60% to 70% on type I and type II DM patients. Methods of data collection carried out prospectively. Data were obtained from outpatient data with a diagnosis of diabetic neuropathy who met the inclusion criteria and received analgetics from September to December 2020. Then a cost-effectiveness analysis was performed by calculating the ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio) values. The results showed that the most commonly used analgetics was gabapentin at 65.96%, either alone or in combination with an effectiveness percentage of 83.87%. The use of analgetics with the lowest cost is a single Paracetamol of IDR 73,770. The lowest ACER values were shown in the use of the single analgetics Paracetamol and the combination of Amitriptyline-Paracetamol, namely 737.70 and 805.30.

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References

Balakumar, P., Arora, M. K., Ganti, S. S., Reddy, J., & Singh, M. (2009). Recent advances in pharmacotherapy for diabetic nephropathy: Current perspectives and future directions. In Pharmacological Research (Vol. 60, Issue 1, pp. 24–32). https://doi.org/10.1016/j.phrs.2009.02.002

Vinik, A. I., Strotmeyer, E. S., Nakave, A. A., & Patel, C. V. (2008). Diabetic Neuropathy in Older Adults. In Clinics in Geriatric Medicine (Vol. 24, Issue 3). https://doi.org/10.1016/j.cger.2008.03.011

Tesfaye, S., dan Selvarajah, D. (2012). Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy Solomon. Diabetes/Metabolism Research and Reviews, 28(1), 8–14. https://doi.org/10.1002/dmrr.2239

Vinik, A. I., Park, T. S., Stansberry, K. B., & Pittenger, G. L. (2000). Diabetic neuropathies. Diabetologia, 43(8), 957–973. https://doi.org/10.1007/s001250051477

Bansal, V., Kalita, J., & Misra, U. K. (2006). Diabetic neuropathy. In Postgraduate Medical Journal (Vol. 82, Issue 964, pp. 95–100). https://doi.org/10.1136/pgmj.2005.036137

Tambirang, R., Wiyono, W., & Mamarimbing, M. (2018). Evaluasi Penggunaan Dan Outcome Terapi Obat Antinyeri Pada Pasien Diabetik Neuropati Di Instalasi Rawat Inap RSUP Prof. Dr. R. D. Kandou Manado. Pharmacon, 7(3), 76–88.

Deshpande, A. D., Haris-Hayes, M., & Schootman, M. (2008). Diabetes-Related Complications. American Physical Therapy Association, 88(11), 1254–1264.

Boyle, J., Eriksson, M. E. V., Gribble, L., Gouni, R., Johnsen, S., Coppini, D. V., & Kerr, D. (2012). Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: Impact on pain, polysomnographic sleep, daytime functioning, and quality of life. Diabetes Care, 35(12), 2451–2458. https://doi.org/10.2337/dc12-0656

Singleton, J. R., & Smith, A. G. (2012). The diabetic neuropathies: Practical and rational therapy. Seminars in Neurology, 32(3), 196–203. https://doi.org/10.1055/s-0032-1329195

Huizinga, M. M., & Peltier, A. (2007). Painful Diabetic Neuropathy : A Management-Centered Review. 25(1), 6–15.

Moore, R. A., Wiffen, P. J., Derry, S., & Rice, A. S. C. (2014). Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database of Systematic Reviews, 2017(3). https://doi.org/10.1002/14651858.CD007938.pub3

Tanenberg, R. (2009). Diabetic peripheral neuropathy: Painful or painless. Hosp Physician, December, 1–8. http://t.turner-white.com/memberfile.php?PubCode=hp_dec09_neuropathy.pdf

Snedecor, S. J., Sudharshan, L., Cappelleri, J. C., Sadosky, A., Mehta, S., & Botteman, M. (2014). Systematic review and meta-analysis of pharmacological therapies for painful diabetic peripheral neuropathy. Pain Practice, 14(2), 167–184. https://doi.org/10.1111/papr.12054

Argoff, C. E., Backonja, M. M., Belgrade, M. J., Bennett, G. J., Clark, M. R., Cole, B. E., Fishbain, D. A., Irving, G. A., McCarberg, B. H., & McLean, M. J. (2006). Consensus guidelines: Treatment planning and options. Mayo Clinic Proceedings, 81(4 SUPPL.). https://doi.org/10.1016/S0025-6196(11)61475-4

Bril, V., England, J., Franklin, G. M., Backonja, M., Cohen, J., Del Toro, D., Feldman, E., Iverson, D. J., Perkins, B., Russell, J. W., & Zochodne, D. (2011). Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology, 76(20), 1758–1765. https://doi.org/10.1212/WNL.0b013e3182166ebe

Tan, T., Barry, P., Reken, S., & Baker, M. (2010). Pharmacological management of neuropathic pain in non-specialist settings: Summary of NICE guidance. BMJ (Online), 340(7748), 707. https://doi.org/10.1136/bmj.c1079

Rahman, P. K. (2020). Analysis of cost effectiveness and utility of amlodipine, micardis, and combination of amlodipine-micardis in hypertention patients at outpatient installation of dr.wahidin sudirohusodo makassar hospital. Tesis. Sekolah Pascasarjana Universitas Hasanuddin Makassarascasarjana Universitas Hasanuddin Makassar.

Abbott, C. A.; Malik, R. A.; van Ross, E. R. E.; Kulkarni, J.; Boulton, A. J. M. (2011). Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K. Diabetes Care, 34(10), 2220–2224. doi:10.2337/dc11-1108

Halawa MR, Karawagh A, Zeidan A, Mahmoud AE, Sakr M, Hegazy A. (2010). Prevalence of painful diabetic peripheral neuropathy among patients suffering from diabetes mellitus in Saudi Arabia. Current Medical Research & Opinion Vol. 26, No. 2, 337–343

Girsang, P. (2020). Faktor Resiko Kejadian Diabetes Melitus Terhadap Pasien Yang Datang Berobat Ke Klinik Asri Wound Medan Tembung Tahun 2019. Jurnal Keperawatan.

Kekenusa, J. S., Ratag, B. T., & Wuwungan, G. (2018). Analisis Hubungan antara Umur dan Riwayat Keluarga Menderita DM dengan Kejadian Penyakit DM Tipe 2 Pada Pasien Rawat Jalan Di Poliklinik Penyakit Dalam BLU RSUP Prof . Dr. R.D Kandou Manado. 000, 1–6.

Finnerup, N.B., Soren Hein Sindrup; Troels Staehelin Jensen (2010). The evidence for pharmacological treatment of neuropathic pain. European Journal of Neurology 2010, 17: 1113–1123. doi:10.1016/j.pain.2010.06.019

Javed S, Petropoulos IN, Alam U, Malik RA. (2015). Treatment of Painful Diabetic Neuropathy. Ther Adv Chronic Dis. 2015;6(1):15 –28.

PERDOSSI. (2016). Diagnostik dan Penatalaksanaan Nyeri Neuropatik. Perhimpunan Dokter Spesialis Saraf Indonesia, 63–67.

Andayani, T. M. (2013). Farmakoekonomi Prinsip dan Metodologi. Bursa Ilmu.Yogyakarta.

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Published

2023-09-30

How to Cite

POLA PENGGUNAAN DAN ANALISIS EFEKTIVITAS BIAYA OBAT ANTINYERI PADA PASIEN DIABETIK NEUROPATI DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG. (2023). Jurnal Riset Kefarmasian Indonesia, 5(3), 384-410. https://doi.org/10.33759/jrki.v5i3.390

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