Jurnal Riset Kefarmasian Indonesia https://jurnalfarmasi.or.id/index.php/jrki <p>"<strong>The Jurnal Riset Kefarmasian Indonesia</strong>" &nbsp;is Journal of Pharmaceutical and Health Science published by APDFI Organization (Asosiasi Pendidikan Diploma Farmasi Indonesia) covering Organization of Pharmacy, Medical, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Physical Chemistry, Biology, Microbiology, Tissue Culture, Botany and animals related to pharmaceutical products, Health Analyst, Nutrition and Public Health.</p> <pre id="tw-target-text" class="tw-data-text tw-ta tw-text-small" dir="ltr" data-placeholder="Translation">&nbsp;</pre> en-US fahmipomo@gmail.com (Supomo, S.Si., M.Si., Apt.) jurnal.apdfi@gmail.com (Agus Trimanto,S.I.Pust) Fri, 28 Jan 2022 00:00:00 +0000 OJS 3.1.1.2 http://blogs.law.harvard.edu/tech/rss 60 AKTIVITAS ANTIOKSIDAN DARI DAUN BINTANGUR (Calophyllum inophyllum L.) TERHADAP RADIKAL BEBAS DPPH (1,1 Difenil-2-pikrihidrazil https://jurnalfarmasi.or.id/index.php/jrki/article/view/200 <p><em>Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and highly reactive molecules. Bintangur contains saponins, tannins, flavonoids and alkaloids. In the presence of flavonoids, the purpose of this study is to understand the antioxidant activity of ethanol extracts against DPPH free radicals, and the IC<sub>50</sub> parameter has the highest antioxidant activity. Use ethanol to macerate Bintangur leaf powder. Analyze the content of secondary metabolites in ethanol extracts. Use a spectrophotometer to test the antioxidant activity of the obtained extract against DPPH free radicals at a wavelength of 517 nm, and determine the IC<sub>50</sub> value. Routine was used as a positive control in this study. The results of three repeated studies showed that the IC<sub>50</sub> values ​​of the ethanol extract were 65.49 ppm, 65.76 ppm, and 65.76 ppm, respectively. Average IC<sub>50</sub> value is 55.67 ppm.</em></p> Ahmad Purnawarman Faisal, Pratiwi Rukmana Nasution, Riza Fahlevi Wakidi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/200 Thu, 27 Jan 2022 03:00:50 +0000 POTENSI EKSTRAK N-HEKSAN, DIKLOROMETANA, ETIL ASETAT, DAN ETANOL 70% JAMUR DEWA (Agaricus blazei Murill) TERHADAP SEL MCF-7 https://jurnalfarmasi.or.id/index.php/jrki/article/view/231 <p><em>God mushroom is a functional food. It has pharmacological activity. This content has activity as an anticancer. The purpose of this study was to conduct a preliminary test to obtain an active ingredient capable of having anticancer activity on MCF-7 cells. The stages of the research are stratified extraction with several solvents. Extraction using maceration. The resulting extract was identified and tested for the anticancer activity of MCF-7 cells. The test uses the TLC method. The stationary phase with silica GF254, the mobile phase is n-hexane: ethyl acetate. Anticancer activity test using the MTT method. The results of the identification of each extract contained terpenoid secondary metabolites. Anticancer activity of MCF-7 cells with IC50 extract of n-hexane 15.0923 µg/ml, dichloromethane extract 17.4213 µg/ml, ethyl acetate extract 10.9132µg/ml with strong cytotoxicity criteria, while for ethanol extract IC50 675, 1236 µg/ml.</em></p> Misgiati - Misgiati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/231 Thu, 27 Jan 2022 23:41:44 +0000 TINGKAT PEMAHAMAN TENAGA TEKNIS KEFARMASIAN TERHADAP OBAT PATEN DAN OBAT GENERIK DI KOTA PADANG https://jurnalfarmasi.or.id/index.php/jrki/article/view/230 <p><em>Patent drugs are drugs that still have patent rights and can only be produced by the manufacturer of the patent holder. while generic drugs are drugs whose patents have expired, so that they can be produced by all pharmaceutical companies. The purpose of this study was to determine the level of understanding of the pharmaceutical technical staff of Padang City on patent drugs and generic drugs. This research is a descriptive observational study using data collection instruments in the form of online questionnaires (google forms). The research variable is the respondent's level of understanding of generic and patent drugs. The respondents of this study were Pharmacy Technical Staff of Padang City, aged 20 years, both male and female, as many as 55 respondents. The sampling technique in this study was non-purposive sampling in accordance with the inclusion and exclusion criteria. Determination of the sample size in this study using the Slovin formula with an error rate of 5%. Collecting data by distributing online questionnaires via Google Forms. The data obtained is coded and entered into an Excel worksheet. The results showed that the level of understanding of the pharmaceutical technical staff of Padang City on patent drugs and generic drugs was categorized as sufficient (74.5%).</em></p> Verawaty Verawaty, Irene Puspa Dewi, Fanny Millenia Kota ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/230 Fri, 28 Jan 2022 12:21:44 +0000 UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TABAT BARITO (Ficus deltoidea) TERHADAP BAKTERI Bacillus substillis DENGAN TINGKATAN POLARITAS PELARUT https://jurnalfarmasi.or.id/index.php/jrki/article/view/229 <p><em>Tabat barito leaf (Ficus deltoidea) is a single leaf of a sole form, the leaf has round tip with a flat edge and a pointed base. These leaves have a smooth surface, coloured green above and brownish yellow beneath. This study aims to determine the antibacterial activity of polar, semi-polar and non-polar compounds contained in Tabat barito leaf extract extracted with solvents of different polarity. The highest bacterial inhibition was also measured against Bacillus substillis which is a gram-positive bacterial. The maceration method uses 3 levels of solvents with different polarities, started with a non-polar solvent (n-hexan), a semi-polar solvent (ethyl acetate) and finally macerated with a polar solvent (methanol). The bacterial activity test was done with &nbsp;diffusion method. The results showed that the Tabat Barito leaf extract contained antibacterial compounds that were non-polar, semi-polar and polar. The highest inhibition of the hexane extract at concentration 15% with a clear zone diameter of 22.33 mm in very strong inhibition category against Bacillus substilis bacteria</em></p> Sri Rahayu, Noor Amaliah, Raudatul Patimah ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/229 Fri, 28 Jan 2022 12:47:08 +0000 PERSEPSI MAHASISWA DALAM PEMBELAJARAN DARING PADA MATA KULIAH FARMASI SIMULASI DI MASA PANDEMI COVID-19 https://jurnalfarmasi.or.id/index.php/jrki/article/view/214 <p><em>This study aims to determine student perceptions of online learning in simulated pharmacy courses during the Covid-19 pandemic. This type of research is descriptive research.</em> <em>Sampling used a purposive sampling technique with clear inclusion criteria,</em> <em>namely students who had received a simulated pharmacy practice course in the fifth semester of the Pharmacy Department of the Health Polytechnic of the Ministry of Health of Palembang as many as 77 students</em><em>. </em><em>Questionnaires distributed via google form with a Likert-scale and one essay question. Analysis of the data is used by calculating the percentage of respondents and analyzing each indicator. The research results obtained are good perceptions from students of online learning in simulated pharmacy courses during the Covid-19 pandemic. </em><em>The score for the percentage of respondents obtained for the teaching and learning process indicators shows good criteria of 72.7%, </em><em>for lecturers' competence indicators showed good criteria of 79.2%, while for facilities and infrastructure indicators also showed good criteria of 75.1%</em></p> Lilis Maryanti, Mona Rahmi Rulianti, Yuliani Yuliani ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/214 Fri, 28 Jan 2022 13:50:12 +0000 GAMBARAN INTERAKSI OBAT PENYAKIT JANTUNG KORONER DENGAN SINDROM METABOLIK PADA PASIEN RAWAT JALAN DI RS TK II DR. SOEPRAOEN MALANG https://jurnalfarmasi.or.id/index.php/jrki/article/view/222 <p><em>Drug interaction is the effect of a drug that is caused when there are two or more drugs that interact and affect the body's response to treatment. The method used in this study is a descriptive study using a cross-sectional observational method with retrospective observations in October - December 2020. Patient data collection was obtained from patient medical records using a purposive sampling technique with inclusion criteria. A total of 89 patients were taken as samples. Data analysis using MEDSCAPE and drugs.com applications. A total of 82 prescriptions have the potential for drug interactions, where the most significant level of drug interaction is moderate level (81.48%, these include aspirin with candesartan and bisoprolol with amlodipine. The most drug interaction is the interaction between aspirin and bisoprolol which is classified as a minor interaction (17.74%). The most frequently used type of drug is bisoprolol (22.18%) and the most frequently used drug class is beta blocker</em></p> Rakhmadani Gadis Aprilianti, Beta Herilla Sekti, Lilik Nur Hidayati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/222 Fri, 28 Jan 2022 14:09:33 +0000 IDENTIFIKASI PARASETAMOL DALAM JAMU PEGAL LINU YANG DIPEROLEH DARI DEPOT JAMU DI KOTA DENPASAR https://jurnalfarmasi.or.id/index.php/jrki/article/view/208 <p><em>The use of traditional medicine in the form of herbal medicine is in great demand by the people of Indonesia, one of that is pegal linu herb. Based on PERMENKES No. 006/Menkes/Per/V/2012 articles 33 and 37 states that traditional medicine may not contain medicinal chemical. Medicinal chemical that is often added into herbal medicine for pegal linu herb is paracetamol.This study aims to determine the presence of paracetamol in pegal linu herb depots in Denpasar city.</em> <em>The research method used an exploratory descriptive method and samples of herbal medicine were taken by purposive sampling, 14 samples of herbal medicine of various brands that was sold at depots in Denpasar City. The research was conducted at the chemical laboratory of Bali International University in July 2021. After preparation, the fourteen samples of herbal medicine were identified using Thin Layer Chromatography (TLC) with selection mobile phase ethanol p.a, detection with UV light 254 nm and 0.05 M H2SO4 sprayer. Completeness identification was also carried out descriptive labeling of herbal products containing paracetamol.&nbsp;</em><em>Positive samples contain paracetamol if the Rf value and spot color are similar to the paracetamol comparison standard. The Rf results obtained that samples with codes F, I, K, and L were 0.68; 0.68; 0.68 and 0.68 which are the similar as the standard Rf for comparison of paracetamol and positive control which is 0.69. The conclusion of the research is that there are various brands of pegal linu herb sold in Indonesia that are suspected to contain 4 brands of paracetamol. Research suggestions for consumers who consume a brand of traditional herbal medicine are expected to be more selective in choosing herbal medicine by first checking the product registration number.</em></p> Maharia Ningsih Ni Made ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/208 Fri, 28 Jan 2022 14:42:05 +0000 FORMULASI HARD CANDY DARI SARI BUAH JERUK NIPIS (Citrus aurantifolio), MADU (Mell depuratum) DAN KAYU MANIS (Cinnamomum burmanii) BERDASARKAN PERBEDAAN SIRUP GLUKOSA https://jurnalfarmasi.or.id/index.php/jrki/article/view/212 <p><em>Lime</em><em> is a fruit that is widely used by people for treatment cough. For efficiency use of lime, it can processing to product that easier for using such as hard candy. This study aims to determine the results of physical tests and panelists preference for hard candies made from lime juice, honey and cinnamon. The method used is an experimental method by combining lime juice, honey, cinnamon and varying glucose syrup as a candy forming ingredient. Physical evaluation of each formula which includes analysis of water content and ash content, also hedonic test of 3 formulas to 100 panelists. The results of the physical evaluation carried out on the 3 formulas showed that all formulas met the quality requirements of SNI 3547.1:2008 hard candy for water content and ash content, also the results of the hedonic test using non parametric SPSS showed that there was a significant effect on taste and texture where formula III was the most preferred by panelist.</em></p> Mega Yulia, Fadhilla Putri Azra, Riki Ranova ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/212 Fri, 28 Jan 2022 15:01:36 +0000 TREN PENGGUNAAN ANTIBIOTIKA LINI 3 DI RS X BEKASI PERIODE TRIWULAN I TAHUN 2020 DIBANDINGKAN DENGAN TRIWULAN IV TAHUN 2019 https://jurnalfarmasi.or.id/index.php/jrki/article/view/227 <p><em>Antibiotics are the most widely used drugs in the treatment of infections caused by bacteria. Resistance of microorganisms to antibiotics, pharmacokinetic and pharmacodynamic factors, drug interactions and side effects and cost factors are needed to be considered in their use. The use of antibiotics needs to be evaluated quantitatively and qualitatively. The study was conducted to determine and evaluate the use of line 3 antibiotics quantitatively in the X Bekasi Hospital in the first quarter of 2020 compared to the fourth quarter of 2019. It was descriptive study with retrospective data collection using total sampling technique. There are 13 types of antibiotics that are included in the line 3 antibiotics used at X Bekasi Hospital. The percentage of use of line 3 antibiotics in the first quarter of 2020 compared to the fourth quarter of 2019 increased by 26.9% for the use of amikacin 250 mg injection but decreased by 100% for the use of amikacin 500 mg injection, increased by 17.8% for the use of meropenem 0.5 g injection but decreased by 16.1% for the use of meropenem 1 g injection, decreased by 100% for the use of imipenem-cilastatin injection, linezolid 600 mg injection and vancomycin 500 mg injection, decreased by 212.5%, 53.6%, 41.2% and 69.2% each for the use of doripenem 500 mg injection, decreased, ceftazidime 1 g injection, cefepime 1 g injection and piperacillin tazobactam injection, and increased 75% for the use of tigecycline 50 mg injection. The use of line 3 antibiotics in X Bekasi Hospital was very large and varied in the fourth quarter of 2019 compared to the first quarter of 2020. A very significant amount was seen in the use of imipenem-cilastatin injection, linezolid 600 mg injection and vancomycin 500 mg injection.</em></p> Kurniatul Hasanah ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/227 Fri, 28 Jan 2022 15:42:10 +0000 EVALUASI SEDIAAN MASKER GEL PEEL-OFF KOMBINASI EKSTRAK DAUN MANGGA BACANG (Mangifera foetida)DAN DAUN SALAM (Syzygium polyanthum) https://jurnalfarmasi.or.id/index.php/jrki/article/view/218 <p><em>Mango Bacang leaves and bay leaves are plants that can be used as ingredients in traditional medicine as natural antibacterials which are believed to help get rid of acne. &nbsp;Several previous studies also reported that Bacang mango leaves and bay leaves have activity against Staphylococcus aureus, Escherichia coli and Salmonella typhi bacteria.&nbsp; This study aims to determine the evaluation results of peel-off gel mask preparations that meet the requirements.&nbsp; The test methods include organoleptic test, pH test, viscosity, homogeneity test and dispersion test.&nbsp; The test results showed that F1 and F2 were the best formulas with the characteristics of a green-black gel, a characteristic odor of mango Bacang and bay leaves, a viscosity of 1129 cPs and 1135 cPs, pH 4.4 and 4.5.&nbsp; The dispersion test was 5.1 cm and 5.7 cm and the homogeneity test on the peel off gel mask was homogeneous, there were no fibers, lumps or differences in color when applied to a transparent slide.</em></p> Kony Putriani, Dini Mardhiyani, Lovera Anggraini ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/218 Fri, 28 Jan 2022 00:00:00 +0000 FORMULASI EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill) DAN DAUN SIRIH (Piper betle) SEBAGAI REPELLANT (ANTI NYAMUK) BERBENTUK MAT ELEKTRIK TERHADAP NYAMUK Aedes aegypti https://jurnalfarmasi.or.id/index.php/jrki/article/view/219 <p><em>The epidemiology and area of the spread of DHF is increasing along with the increasing mobility and population density. One of the efforts made in eradicating mosquito vectors is by using insecticides.</em> <em>This study aimed to examine the effectiveness of the combination of avocado (Persea americana) and betel leaf (Piper betle) ethanol extracts against the death of Aedes aegypti mosquitoes. </em><em>This study aimed to examine the effectiveness of the combination of avocado (Persea americana) and betel leaf (Piper betle) ethanol extracts against the death of Aedes aegypti mosquitoes. This research design is experimental with post test only control group design. The electric mat that had been soaked with a combination of ethanolic extract of avocado (Persea americana) and ethanolic extract of betel leaf (Piper betle) was divided into 4 concentration groups, namely positive control, negative control, and a combination of extracts with concentrations of 1%, 3% and 5 %. Then tested with 10 Aedes aegypti mosquitoes in each treatment</em><em>. Then tested with 10 Aedes aegypti mosquitoes in each treatment. The results showed that at a concentration of 5% it was able to kill 10 Aedes aegypti mosquitoes in just 5 minutes compared to concentrations of 1% and 3%. From this study it can be concluded that the greater the concentration of extract used, the faster the duration of time to kill the Aedes aegypti mosquito.</em></p> Arifuddin Yunus, Dwi Fitrah Wahyuni, An Nisaa Nurzak ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 https://jurnalfarmasi.or.id/index.php/jrki/article/view/219 Sun, 30 Jan 2022 12:34:41 +0000