Jurnal Riset Kefarmasian Indonesia https://jurnalfarmasi.or.id/index.php/jrki <p>"<strong>The Jurnal Riset Kefarmasian Indonesia</strong>" &nbsp;is Journal of Pharmaceutical and Health Science published by APDFI Organization (Asosiasi Pendidikan Diploma Farmasi Indonesia) covering Organization of Pharmacy, Medical, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Physical Chemistry, Biology, Microbiology, Tissue Culture, Botany and animals related to pharmaceutical products, Health Analyst, Nutrition and Public Health.</p> <pre id="tw-target-text" class="tw-data-text tw-ta tw-text-small" dir="ltr" data-placeholder="Translation">&nbsp;</pre> APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) en-US Jurnal Riset Kefarmasian Indonesia 2655-8289 ISOLASI SENYAWA AKTIF DAN UJI AKTIVITAS EKSTRAK JAHE MERAH (ZINGIBER OFFICINALE) SEBAGAI IMUNOMODULATOR https://jurnalfarmasi.or.id/index.php/jrki/article/view/131 <p><em>Red ginger (Zingiber officinale) contains many chemical compounds that have many activities. This study aims to determine the active compounds of Zingiber officinale and immunomodulatory activity that can increase the phagocytosis of macrophage cells and lymphocyte cell proliferation. Red ginger extract compounds were identified using GC-MS. The parameters of immunostimulatory activity were macrophage phagocytosis and lymphocyte proliferation, the preparations were made in several extract concentrations. This research is an experimental study in the laboratory. The research included fresh red ginger, made into ethanol extract, dried. The results were made a suspension, the extract was then given to macrophage cells (phagocytosis testing) and lymphocyte cells (proliferation testing) in vitro to test the immunomodulatory effect. The results showed that the most active extract in macrophage phagocytosis activity was the extract concentration of 500 ppm. While the activity of lymphocyte proliferation was shown by the concentration of group A (Cell, 500 ppm extract, MK, Engerik). The active compound contained in the ethanol extract of red ginger is thought to be Geraniol</em></p> Masniah Masniah Jafril Rezi Ahmad Purnawarman Faisal ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-26 2021-05-26 3 2 77 91 10.33759/jrki.v3i2.131 PENGENDALIAN PENGELOLAAN OBAT DI INSTALASI FARMASI SUATU RUMAH SAKIT SWASTA KOTA BANDUNG https://jurnalfarmasi.or.id/index.php/jrki/article/view/134 <p><em>Drug management is a series of planning, procurement, storage, distribution, and control activities carried out by a hospital pharmacy so that drug availability can be guaranteed in sufficient quantities, in its implementation requires a large number of funds. The study was conducted to evaluate drug management in private hospital pharmacies in the city of Bandung using predetermined standard indicators. This study used a retrospective non-experimental observational method. The data collected is in the form of planning data and drug procurement, drug use, drug stock cards, stock-taking reports. The results showed that the achievement of drug planning </em><em>(</em><em>107.53%</em><em>)</em><em>, the frequency of purchase for the low category</em><em> (</em><em>34.70%</em><em>)</em><em>, the medium category was 41.08% and the high category</em><em> (</em><em>24.22%</em><em>)</em><em>, expired drugs </em><em>(</em><em>0.085%</em><em>) </em><em>and the dead stock </em><em>(</em><em>3.81%</em><em>).</em></p> Ida Lisni Herman Samosir Ester Mandalas ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-26 2021-05-26 3 2 92 101 10.33759/jrki.v3i2.134 OPTIMASI CAMPURAN AVICEL PH 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SECARA GRANULASI BASAH https://jurnalfarmasi.or.id/index.php/jrki/article/view/124 <p><em>Rosella flower (Hibiscuss sabdariffa L.) in traditional medicine can provide protection against various diseases, such as coronary heart disease, cancer, lowering cholesterol, and liver disorders. This study aims to obtain the optimum formula of tablet of rosella flower extract with a mixture of Avicel PH 101 and lactose as a filler using wet granulation method. Rosella flower extract was obtained by maceration of rosella flower powder using 70% ethanol. The optimization formula for tablets using the Simplex Lattice Design method with Design Expert software version 10. The parameters used in the optimization are weight variation, hardness, friability and disintegration time. Verification of the optimal formula using the SPSS 18 program with the One Sample T-test method with a confidence level of 95%. The results showed that the optimal formula of tablet of rosella flower extract was the Avicel PH 101 97.82%: 2.17% lactose. The optimal formula has weight variation 1.53% ± 0.0073; hardness 5.087 kg ± 0.5135; the friability is 0.3% ± 0.041. The resulting disintegration was 22.99 minutes ± 2.218. The results of the verification of the optimal formula show that there is no significant difference between the predictions of the Simplex Lattice Design method and the results of the tests performed so that it can be said that the method is valid.</em></p> Zila Tjhia Kokafrinsia Dwi Saryanti ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-30 2021-05-30 3 2 102 116 10.33759/jrki.v3i2.124 GAMBARAN PERSEDIAAN OBAT DI APOTEK NIAS MEDIKA DENGAN ANALISIS ABC BERDASARKAN RESEP MASUK PERIODE JANUARI-MEI 2020 https://jurnalfarmasi.or.id/index.php/jrki/article/view/140 <p><em>Pharmacy is a pharmaceutical service facility where pharmacy practices are carried out by pharmacists, namely manufacturing including quality control of pharmaceutical preparations, security, procurement, storage and distribution or distribution of drugs, drug management, prescription drug services, drug information services, and drug development services, drug ingredients and traditional medicine One of the scopes in the management of health services is logistics management, which is a field of management whose specific task is to deal with logistics. Pharmacy nias medika there was no specific arrangement for the procurement of drugs with certain methods so that often there is a vacuum of medicine one of which is for drugs contained in a doctor's prescription that goes to the nias medika pharmacy. For this reason, it was necessary to control drug inventory using certain methods, one of which was by using ABC analysis. The type of research was descriptive and quantitative, based on the prescription entry by recording the name of the drug, the number of drugs, and the unit price of the drug and then processed using data analysis during January-May 2020. The results showed that there were 160 types of drugs based on prescription entry into the drugstore nias medika. With 32 types (20% ) drugs classified as group A with an investment value of 69.68% with laroton drugs which are in the highest position 47 types (29.37%) drugs classified as group B with an investment value of 20.25%, while 81 types (50, 63%) the drugs belong to group C with a total investment of 10.07%.</em></p> Vonny Nofrika Ika Agustina Risca Priyanti ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-30 2021-05-30 3 2 117 125 10.33759/jrki.v3i2.140 PENGARUH KOMUNIKASI TENAGA FARMASI DALAM UPAYA PENINGKATAN PEMAHAMAN LANSIA TERHADAP DAGUSIBU OBAT (DAPATKAN, GUNAKAN, SIMPAN, BUANG) DI DESA KOPEN KABUPATEN BOYOLALI https://jurnalfarmasi.or.id/index.php/jrki/article/view/135 <p><em>Irrational use of drugs and their abusers is a problem that is often found in society.&nbsp; Based on the survey data obtained, there are still residents who get drugs freely without monitoring medical and pharmaceutical personnel or the drugs purchased are medicines from grocery stores, and many residents in Kopen village, Boyolali, do not know how to use appropriate drugs and how to store them.&nbsp; The correct medicine and many of them are still throwing away liquid medicine in the package and without paying attention to damage the medicine package. Education about the drug Dagusibu is one of the efforts we do as pharmaceutical personnel to prevent irrational drug use and to prevent drug abuse by the community, especially the elderly in Kopen Village, Boyolali.&nbsp; The method used is a preventive intervention method and a quantitative approach to the elderly using the Dagusibu questionnaire that we created.&nbsp; Based on filling out the questionnaire before we do the socilization, it was found that 73% of the elderly who do not understand, 18% of the elderly who have little understanding and 7% of the elderly who are accompanied by a guardian who already understands. The understanding of Dagusibu drugs by the elderly in the Village Kopen, Boyolali categorized't get it. It needs to be held socialization to improve the understanding of the elderly and also residents in the Village kopen, Boyolali. After socialization, the obtained results of the questionnaire 27% still do not understand, 64% already understand and also 9% are elderly, accompanied by a guardian in the use of the drug. The conclusion of this research is the role of pharmaceutical personnel hold a very important role in conveying information and education in an improved understanding of the elderly and residents in the Village kopen, Boyolali..</em></p> Amanda Anisawati Faizatul Isma Ilham La Tansa Rafidah Hanifah Rizky Nur Diana Aris Prio Agus Santoso ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-31 2021-05-31 3 2 126 137 10.33759/jrki.v3i2.135 UJI IN VIVO TAHAP PREKLINIS TERHADAP EKSTRAK BATANG PISANG (Musa paradisiaca L.) SEBAGAI ANTIINFLAMASI TOPIKAL https://jurnalfarmasi.or.id/index.php/jrki/article/view/129 <p><em>Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical damage, or microbiological substances. Banana stems (Musa paradisiaca L.) have been empirically believed for their topical anti-inflammatory properties. The purpose of this study was to scientifically evaluate the in vivo preclinical anti-inflammatory activity of banana stems. This research was designed experimentally using twenty-five albino male rats which were divided into five groups: the positive control group which received sodium diclofenac gel, the negative control group which received gel basis preparation without any active ingredient, and three experimental groups which received banana stem extract gel in three different concentrations, 5%, 10%, and 15%. Every five rats of every group were firstly injected with 1% of carrageenan, and the anti-inflammatory effect was evaluated every hour for 4 hours using a plethysmometer.&nbsp; The collected data were statistically evaluated. The results showed that banana stem extract gel with concentrations of 15% produced the best anti-inflammatory effect, compared to other gel concentrations. In conclusion, the preparation of 15% banana stem extract gel can be applied as potential topical anti-inflammatory preparation.</em></p> Ni Luh Kade Arman Anita Dewi Putu Era Sandhi Kusuma Yuda I Gede Agus Suarnata Maria Malida Vernandes Sasadara ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-31 2021-05-31 3 2 138 151 10.33759/jrki.v3i2.129