Jurnal Riset Kefarmasian Indonesia
https://jurnalfarmasi.or.id/index.php/jrki
<p><strong>Jurnal Riset Kefarmasian Indonesi (JRKI)</strong> adalah Jurnal dengan akses terbuka (Open Access) yang memuat artikel tentang ruang lingkup kefarmasian seperti Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang berkaitan dengan produk farmasi, Analis Kesehatan, Gizi serta Kesehatan Masyarakat.</p> <p>Jurnal ini diterbitkan 3x dalam satu tahun yaitu dibulan <strong>Januari, Mei dan September. </strong>Jurnal Riset Kefarmasian Indonesia (JRKI)<strong> </strong>ditetapkan sebagai Jurnal Ilmiah Terakreditasi Peringkat 5 (Sinta 5) berdasarkan Keputusan Menteri Riset dan Teknologi/Kepala Badan Riset dan Inovasi Nasional Nomor: 158/E/2021 dengan masa berlaku mulai <strong>Volume 1 Nomor 3, Th 2019</strong> hingga <strong>Volume 6 Nomor 2, Th 2023</strong></p> <p><strong>Jurnal Riset Kefarmasian Indonesia (JRKI) </strong>telah terindeks di Google Scholar, PKP Index, One Search Indonesia (IOS), Garuda Dikti, Crosreff, Dimension, Neliti dan SINTA Kemendikbud Dikti.</p>APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)enJurnal Riset Kefarmasian Indonesia2655-8289ANALISIS EFEKTIVITAS BIAYA BEBERAPA MOISTURIZER
https://jurnalfarmasi.or.id/index.php/jrki/article/view/512
<p>The growth of e-commerce continues to increase in Indonesia, one of which is the Shopee application which can buy goods, sell various kinds of products, and shop safely. Shopee showed in early 2020 that the beauty category ranked highest in the best-selling product categories, one of which was Moisturizer. The purpose of this study was to determine the comparison of each moisturizer which is more cost effective. This type of research uses a true experimental method with a posttest only control group design to determine the before and after conditions between the control group (no moisturizer) and the experimental group (moisturizer X, moisturizer Y, moisturizer Z). The sample of this study consisted of 20 volunteers with observations carried out for 4 weeks to obtain the effectiveness of moisture recovery, pores, blemishes, wrinkles. The results showed that moisturizer Z for moisture is more cost effective with an ACER value of Rp. 859 ICER Rp. 886. While moisturizer Y for pores is more cost effective with an ACER value of Rp. 2,515 ICER Rp. 2,800. While moisturizer Y for blemishes is more cost effective with an ACER value of Rp. 2,427.7 ICER Rp. 2,581. Then moisturizer Z for wrinkles is more cost effective with an ACER value of Rp. 1,846 ICER Rp. 2,307. In conclusion, moisturiser C is the most cost effective for moisture and wrinkles while moisturiser B is more cost effective for pores and blemishes<em>.</em></p>
ArticlesACER; analisis efektivitas biaya; ICER; moisturizer; shopee clinical and community pharmasiEva Sartika DasopangFenny HasanahDesy Natalia SiahaanPutri Salsabila
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-312024-01-3111112110.33759/jrki.v6i1.512PERBANDINGAN TOTAL SENYAWA FLAVONOID EKSTRAK ETANOL KULIT DAN BIJI BUAH OKRA HIJAU (Abelmoschus esculentus L.)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/424
<p><em>Green okra (Abelmoschus esculentus L.) is a plant belonging to the Malvaceae family. Green okra fruit contains many secondary metabolites, one of which is flavonoids, which have potential as antioxidants to stabilize free radicals. This study aims to determine and compare the total flavonoid content of seeds and skin, so that it can be ascertained which part of the fruit has the highest total flavonoid content. The okra fruit extraction process was carried out by maceration with 70% ethanol solvent. Phytochemical screening and thin layer chromatography tests were performed on green okra seeds and skin extracts. The total flavonoid content was determined using the colorimetric-aluminum chloride method with UV-Vis spectrophotometry. The results of the phytochemical screening showed that the ethanol extract of green okra fruit peels contained alkaloids, flavonoids, tannins, and steroids, while the ethanol extract of green okra fruit seeds contained alkaloids, flavonoids, saponins, and tannins. The results of the thin layer chromatography test showed that the ethanol extract of green okra fruit skin and seeds contained a flavonoid compound as quercetin. The results of the total flavonoid content of the ethanol extract of green okra fruit skin : okra fruit seeds were 6.4589 mg QE/g extract ± 0.86 : 27.7583 mg QE/g extract ± 0.36. Based on statistical results with an Independent T test using SPSS, the significance value (2-tailed) of both samples was < 0.05, which means that there is a real difference between the total flavonoid compounds of skin ethanol extract and ethanol extract of green okra fruit seeds.</em></p>
ArticlesBiji okra hijau, kulit okra hijau, kadar flavonoid totalDharma YantiIndah Ananda Putri
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-312024-01-3116317810.33759/jrki.v6i1.424PENGEMBANGAN FORMULASI EMULGEL FRAKSI n-HEKSAN DAUN MIANA (Coleus scutellarioides) SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acnes PENYEBAB JERAWAT (Acne vulgaris)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/431
<p><em>Acne (Acne vulgaris) is a condition where the skin experiences inflammation in the polysebaceous unit which is triggered by Propionibacterium acnes. Miana leaves (Coleus scutellarioides) contain alkaloid and terpenoid compounds which can act as antibacterials. This research aims to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) can be formulated in the form of a physically and chemically stable emulgel preparation, to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) has activity against P. acnes. as a cause of acne (A. vulgaris) and to determine the formula with an effective concentration in inhibiting the growth of P. acnes. This research is a form of laboratory experimentation. The n-Hexane fraction of miana leaves was obtained by fractionation. Antibacterial activity testing was carried out using the well method. The results obtained were physically and chemically stable emulgel formulas, namely F0 and F1. The inhibition zone of F1 is 16.46 mm (strong), F2 is 14.40 mm (strong), F3 is 16.78 mm (strong) and F0 has no antibacterial activity. The formula with a concentration of 12.5% was the most effective in inhibiting the growth of P. acnes, namely 16.78 mm. From the results of this research, it was found that the n-Hexane fraction of Miana leaves (C. scutellarioides) has strong antibacterial activity against P. acnes and can be formulated in the form of an emulgel dosage form.</em></p>
ArticlesJerawat, Antibakteri, Miana, Propionibacterium acnes, emulgelNielma AuliahNurjannah BachriMuhammad Asri SRNurfatma Nurfatma
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-302024-01-30637810.33759/jrki.v6i1.431GAMBARAN FUNGSI GINJAL PASIEN DIABETES MELITUS TIPE II DI PUSKESMAS TLOGOSARI KULON KOTA SEMARANG
https://jurnalfarmasi.or.id/index.php/jrki/article/view/476
<p style="text-align: justify; text-indent: 36.0pt; line-height: 150%; margin: 6.0pt 2.2pt .0001pt 0cm;"><em><span lang="EN-US">Type II Diabetes Mellitus (DMTII) patients who are not treated properly can experience decreased renal function. The use of oral hypoglycemic drugs (OHG) can cause a decrease in renal function. Glomerular Filtration Rate (GFR) can describe a decrease in renal function. The aim of this study was to determine the description of renal function in DMTII patients at the Tlogosari Kulon Health Center, Semarang City. This research is a descriptive observational study. The sampling technique used was purposive sampling. Data was obtained from medical records of DMTII patients for the period September–December 2022. The inclusion criteria were patients with DMTII who received OHG therapy for at least one year, aged ≥45 years, had the most recent serum creatinine examination, with or without comorbidities. If the patient's data is incomplete or the patient has a history of renal problems, they will be excluded. Based on the research results, it was discovered that there were 55 DMTII patients, consisting of 39 patients (70.90%) women and 16 patients (29.10%) men. A total of 29 patients were aged between 60-69 years (52.73%). A total of 39 patients had comorbidities such as hypertension and/or dyslipidemia. A total of 76.36% received OHG combination therapy. Forty percent of patients experienced a decrease in GFR from mild-moderate to severe. The decrease in GFR is caused by the amount of OHG consumed and comorbid hypertension</span></em></p>
ArticlesPuskesmasDM Tipe IIFungsi GinjalClinical pharmacyFef RukminingsihCarla Julianti
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-302024-01-30374810.33759/jrki.v6i1.476UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL dan FRAKSI DAUN SEMBUNG (Blumea balsamifera L.) TERHADAP BAKTERI Staphylococcus epidermidis
https://jurnalfarmasi.or.id/index.php/jrki/article/view/440
<p><em>Sembung Leaves (Blumea balsamifera L.) is a plant with many properties, one of which is antibacterial. Sembung leaves have several chemical compounds such as tannins, saponins, and flavonoids which function as antibacterials. This study aims to determine the diameter of inhibition zone, the value of Minimum Inhibition Concentration (MIC) dan the value of Minimum Bactericidal Concentration (MBC) of ethanol extract, n-hexane fraction, ethyl acetat fraction and water fraction of sembung leaves (Blumea balsamifera L.) against the staphylococcus epidermidis bacteria. Antibacterial testing by using disc diffusion dan solid dilution methods. Ethanol extract and fractions of sembung leaf (Blumea balsamifera L.) that has been obtained are diluted with a concentration of 10%, 25%, and 50%. The positive control as clindamycin 1% and DMSO as the negative control. The results showed that ethanol extract of sembung leaves (Blumea balsamifera L.) can inhibit the growth of Staphylococcus epidermidis bacteria at a concentration of 10% which is 8,1 mm, concentration of 25% which is 9,13 mm, concentration of 50% which is 10,1 mm. The n-hexane fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10 % which is 6,1 mm, concentration of 25% which is 7,11 mm, concentrarion of 50% which is 7,21 mm. The ethyl acetate fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10% which is 9,1 mm, concentration of 25% which is 11,16 mm, concentration of 50% which is 12,26 mm. The water fraction there is no inhibition zone diameter. The MIC of ethanol extract of sembung leaves is 10%, n-hexane fraction is 25% and ethyl acetate fraction is 10%. The MBC of ethanol extract was at a concentration of 25%, n-hexane fraction at a concentration of 50% and ethyl acetate fraction at a concentration of 10%.</em></p>
ArticlesAntibacterial, Disc Methods, Blumea Balsamifera L., FractionHayatus Sa'adahRagilia PristantiHusnul Warnida
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-302024-01-30496210.33759/jrki.v6i1.440UJI AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT DAN DAGING BUAH NAGA MERAH (Hylocereus polyrhizus) DANPENENTUAN PARAMETER NON SPESIFIK
https://jurnalfarmasi.or.id/index.php/jrki/article/view/485
<p><em>Red dragon fruit is one of the fruits that is often consumed by the Indonesian people because it is rich in properties and benefits.</em><em> </em><em>In addition to the fruit, red dragon fruit skin</em><em> </em><em>can also be used as a natural colorant in food and cosmetics. One of the beneficial compounds contained in the skin and flesh of red dragon fruit is antioxidant.</em><em> </em><em>This study aims to determine the differences in antioxidant activity and non-specific parameters of red dragon fruit skin and flesh extracts.</em><em> </em><em>The samples used are skin and flesh of red dragon fruit, in addition to comparing fresh samples and dried simplisia of each skin and flesh, dried simplisia samples from each skin and flesh. Method extraction method used in this study is reflux method with 70% ethanol solvent. Antioxidant activity was determined by IC<sub>50</sub> value. From the IC<sub>50</sub> calculation, it was found that red dragon fruit peel extract with fresh samples and dry simplisia included strong antioxidants while antioxidants in red dragon fruit flesh were lower with weak antioxidant activity. The difference in the use of simplisia also affects the antioxidant activity of the extract, extracts using dry simplisia have higher antioxidant activity than extracts using fresh samples. While in the test of non-specific parameters of the extract there is no significant effect.</em></p>
Articles Kulit dan daging buah naga merahic50parameter non-spesifikKimia FarmasiFarmasiNuska AliyaAldi Budi RiyantaTya Muldiyana
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-292024-01-2911510.33759/jrki.v6i1.485EVALUASI KESESUAIAN WAKTU TUNGGU PELAYANAN RESEP DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT UMUM KABUPATEN TANGERANG NOVEMBER 2022
https://jurnalfarmasi.or.id/index.php/jrki/article/view/482
<p><em> Service Standards in hospitals related to</em><em> </em><em>pharmaceuticals are divided into several criteria, one of which is the waiting time for</em><em> </em><em>prescription services. Tangerang Regency general hospital is one of the type B</em><em> </em><em>government hospitals, being a referral makes RSU Tangerang Regency experience a</em><em> </em><em>buildup of patients in each polyclinic which results in many prescriptions entering</em><em> </em><em>outpatient pharmacies so that they often experience a buildup of prescriptions that</em><em> </em><em>cause discomfort to patients. The purpose of this study was to determine what is the</em><em> </em><em>average waiting time for outpatient prescription services at Tangerang Regency</em><em> </em><em>General Hospital and the percentage of conformity of non- concoction or concoction</em><em> </em><em>prescriptions with prescription service standards in accordance with the</em><em> ministry of health. </em><em>This study is a descriptive study using primary data, namely waiting</em><em> </em><em>time data recorded directly. Waiting time data obtained from direct observation</em><em> </em><em>during prescription services in outpatient pharmacy installations with research</em><em> </em><em>instruments using excel computer waiting time, data with a total population of 5087</em><em> </em><em>outpatient prescriptions. The data that has been obtained is then analyzed using the</em><em> </em><em>mean formula (average value). </em><em>The results of the research show that the average service for non-concocted drug prescriptions is more than 30 minutes and the average service for prescriptions of concocted medicines is more than 60 minutes, so that the suitability of waiting times for non-concocted and concocted prescriptions is still greater than that which does not comply with the minimum service standards.</em></p>
ArticlesWaktu Tunggu, Standar Pelayanan Minimal, Instalasi FarmasipharmacyAlifa SabrinaLeonov RiantoFarida TuahunsFitri SavitriFery Yulianto
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-312024-01-3114215010.33759/jrki.v6i1.482FORMULASI MASKER GEL PEEL OFF EKSTRAK BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTIOKSIDAN ALAMI
https://jurnalfarmasi.or.id/index.php/jrki/article/view/477
<p><em>Natural ingredients containing antioxidant compounds can be made in the form of a peel-off gel mask which can help care for facial skin. Butterfly pea flowers (Clitoria ternatea L.) contain flavonoid anthocyanin compounds which can break the chain reaction of free radicals. The aim of this research is to determine the antioxidant activity of butterfly pea flower extract and the preparation of butterfly pea peel off gel mask. The peel off gel mask formulation uses butterfly pea flower extract with a concentration of 5%. Testing for antioxidant activity uses the DPPH method. Physical characteristics assessment includes organoleptic tests, homogeneity observations, spreadability tests, viscosity tests, drying time tests, and preparation pH tests. Based on the research results, the IC<sub>50</sub> value of telang flower extract is 43.68 ppm in the very strong category and the IC<sub>50</sub> value of the peel-off gel mask preparation is 307.71 ppm in the inactive category. This research shows that the ethanol extract of butterfly pea flowers has potential as a natural antioxidant.</em></p>
ArticlesBunga Telang, Antioksidan, Masker Gel Peel Off, Ekstrak, EvaluasiAulia Rahmi AzizahAnanda Imroatur RasidahFirdianty Lestari WilujengNor PiyaSiska Dwi YulianiGhina AdhilaReksi Sundu
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-312024-01-3112214110.33759/jrki.v6i1.477FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER WAJAH GEL PEEL-OFF EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/467
<p><em> Red dragon fruit (Hylocereus polyrhizus) has many benefits. The </em><em>fruit peel </em><em>is rich in antioxidants which have the potential to improve the health and beauty of facial skin. Traditional use requires a long preparation time and formulation is needed to make preparations with more effective, practical and long-lasting storage. The facial mask formulation is a peel-off gel preparation that can moisturize the skin and increase the effect of the active ingredients. Quality assurance, namely safety, quality and benefits, is very necessary, which can be done by testing the physical stability of the preparation. The aim of this research is to obtain a formula made from the active ingredient Hylocereus polyrhizus fruit peel extract in the form of a peel-off gel facial mask and the best physical stability. HPMC was used as a carrier base by varying the concentration, namely 2%; 3% and 5%. Evaluation of the physical stability of the preparation was carried out, namely homogeneity, organoleptic, spreadability, viscosity, pH and dry time tests of 14 and 28 days. Storage is carried out at warm (30-40°C), room (15-30°C), and cold (2-8°C) temperatures. The best formula is 3% HPMC concentration with the best physical stability. Variations in storage temperature have an effect on physical organoleptics (color), viscosity and dispersion, but have no effect on physical homogeneity, drying time and pH. Cold temperatures (2-8°C) show the best stability because they can maintain physical stability.</em></p>
ArticlesHylocereus polyrhizus, SuhuStabilitasMasker gel peel-offFarmasetika dan Teknologi FarmasiAgnis Pondineka Ria AditamaRili KusumaningtyasWidya Nuratika KarimahDenok Risky Ayu ParamitaDewi RashatiFaisal Akhmal Muslikh
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-302024-01-30799610.33759/jrki.v6i1.467FERMENTASI BIJI BUAH NANGKA (Artocarpus heterophyllus Lam.) MENGHASILKAN ETANOL OLEH Saccharomyces cerevisiae DENGAN ANALISA KROMATOGRAFI GAS (GC)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/463
<p><em>Research of bioethanol production from jackfruit seeds through fermentation using saccharomyces cerevisiae with the addition of tofu waste as nutrition source of microorganism. the aims of this research to determine the concentration of bioethanol that has been produced with the variation of concentration of tofu waste nutrients and variation of fermentation time. the hydrolysis process through enzymatic uses alfa-amylase on liquefaction process and glucoamylase on saccharification process. the fermentation process used Saccharomyces cerevisiae and tofu waste as a source of nutrition. variation of fermentation time 6, 8 and 10 days and variation of tofu waste nutrients concentration 0,75%; 1,5% and 2,25% (w/v). Ethanol content was obtained by gas chromatography analysis, the result showed the highest concentration of bioethanol obtained at the addition of tofu waste nutrients was 1,5% (w/v) and fermentation time for 10 days with bioethanol concentration obtained at 65,72%.</em></p>
ArticlesBioethanol, Jackfruit Seed (Artocarpus heterophyllus Lam.), Tofu Dregs, Fermentation.Ana FitrianiRudi KartikaErwin Akkas
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3048749710.33759/df0qqc47SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL RIMPANG KUNYIT HITAM (Curcuma caesia Roxb.) ASAL LUWU UTARA DENGAN METODE DPPH
https://jurnalfarmasi.or.id/index.php/jrki/article/view/397
<p><em>The ethanol extract of black turmeric (Curcuma caesia Roxb.) contains flavonoid</em><em>s</em><em> compounds which are thought to have antioxidant activity.The purpose of this study was to determine the class of chemical compounds and determine the IC50 value of the ethanol extract of black turmeric (Curcuma caesia Roxb.)rhizome from North Luwu using the DPPH method. The research method included extraction by maceration using 70% ethanol solvent. Phytochemical screening using specific reagents and antioxidant activity testing using the DPPH method using a visible spectrophotometer at a wavelength of 515 nm. The results of the phytochemical screening showed that the ethanol extract of black turmeric rhizome contained flavonoids, alkaloids, tannins and triterpenoids. The results of the antioxidant activity test showed that the ethanol extract of black turmeric (Curcuma caesia Roxb.) rhizome had an IC<sub>50</sub> value of 108.8304 ± 1.24 μg/mL and ascorbic acid of 2.39 ± 0.04 μg/mL.</em></p>
ArticlesKata kunci: Antioksidan; Curcuma caesia Roxb.; DPPH; Skrining FitokimiaTahirah HasanNur IdaSepti Firqiana Qifni
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3043945710.33759/jrki.v5i3.397FORMULASI KAPSUL ANTIDIABETES EKSTRAK UMBI BAWANG DAYAK (Eleuhterine palmifolia (L) Merr.) DENGAN VARIASI KONSENTRASI AVICEL 101 DAN PREGELATINIZED STARCH
https://jurnalfarmasi.or.id/index.php/jrki/article/view/402
<p><em>Diabetes Mellitus is a heterogeneous disease characterized by improvement glucose levels in the blood. Several studies have shown that Dayak onions have hypoglycemic activity or lowering blood glucose levels which may be very useful for treatment of diabetes mellitus. Flavonoids contained in Dayak onions are in position to restore the characteristics of pancreatic tissue by increasing insulin release through β cells, so that it can lower blood sugar levels and can also increase sensitivity peripheral cells to insulin. Given the great potential of Dayak onions as antidiabetic, it is very important to develop more practical preparations that can carrying out weight uniform measurements of the products used, of course, one of them is in pharmaceutical preparations capsule form. This examination aims to determine the physical properties and antioxidant activity of Dayak onion extract capsules in large quantities concentration of Avicel PH 101 and pregelatinized starch as fillers. Look was carried out experimentally using three formulas with various concentrations fillers with a ratio between Avicel PH 101 and pregelatinized starch, in particular formula I (1:0), formulation II (0.5:0.5) and method III (0:1). body residence and drug stability is checked and then tested for antioxidant hobby spectrophotometric use. The research results show that the formula with the composition of Avicel PH 101 and pregelatinized starch in the ratio (0:1) is given the best wet house physical test results were 3.4%, sliding houses 12.82 gram/second, angle of repose 29.85⁰, compressibility 8%, density 0.544 and destroyed time 3 minutes 37 seconds. along with antioxidant effects activity examination showed that the drug Dayak onion extract proved to be moderate antioxidant activity, specifically 228.78 ppm.</em></p> <p> </p>
ArticlesKadek Agus IndriawanHayatus Sa'adahRusdiati Helmidanora
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3041142610.33759/jrki.v5i3.402PEMANFAATAN LIMBAH KULIT BAWANG PUTIH (Allium sativum L.) SEBAGAI BAHAN AKTIF PEMBUATAN SABUN CAIR
https://jurnalfarmasi.or.id/index.php/jrki/article/view/392
<p><em>Utilization of household waste in Indonesia is still very rarely done, one of which is the use of garlic skin waste. From research by Allemann & Baumann in 2008, garlic skin is rich in antioxidant compounds so it can protect skin cells from free radical damage if used as a skincare product, one of which is liquid bath soap for the body. This research aims to formulate garlic skin extract as liquid soap. The concentration used is 10%. The liquid soap formulation used was 17 g of SLS, 3 g of NaCl, 9 g of Cocamidopropyl Betaine, 9 g of Glycerin, Fragrances, and Dyes to taste. Garlic skin extract liquid soap is evaluated for its physical quality consisting of organoleptic test results in the form of liquid, gum-scented and red-colored, pH test of 8.2, height test and foam stability of 79 mm, moisture content test of 51.12%, specific gravity test of 1.012 g/ml, and irritation test declared non-irritating. The results showed that garlic skin extract liquid soap with a concentration of 10 % had a physical quality that complied with their requirements. This research concludes that garlic skin extracts liquid soap meets the requirements of the physical quality test</em><em> and safe for the skin because it does not cause irritation to the skin when used</em><em>.</em></p>
Articleskulit bawang putih, sabun cair, evaluasi mutu fisikPanji Ratih SSih Wahyu RErna FitriyanyCikra IFinna CalyaSeptiana Sari
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3042743810.33759/jrki.v5i3.392POLA PENGGUNAAN DAN ANALISIS EFEKTIVITAS BIAYA OBAT ANTINYERI PADA PASIEN DIABETIK NEUROPATI DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG
https://jurnalfarmasi.or.id/index.php/jrki/article/view/390
<p><em>Diabetic neuropathy is gathering symptom clinic which influence system nerves, well single or combination and could happen in a manner suddenly, no detected, with symptom clinic and no specific signs but dangerous. Incidence diabetic neuropathy happen between 60% to 70% on type I and type II DM patients. Methods of data collection carried out prospectively. Data were obtained from outpatient data with a diagnosis of diabetic neuropathy who met the inclusion criteria and received analgetics from September to December 2020. Then a cost-effectiveness analysis was performed by calculating the ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio) values. The results showed that the most commonly used analgetics was gabapentin at 65.96%, either alone or in combination with an effectiveness percentage of 83.87%. The use of analgetics with the lowest cost is a single Paracetamol of IDR 73,770. The lowest ACER values were shown in the use of the single analgetics Paracetamol and the combination of Amitriptyline-Paracetamol, namely 737.70 and 805.30. </em></p>
ArticlesDiabetik Neuropati, Obat Antinyeri, Analisis Efektivitas BiayaTri Purma SariDyah Aryani PerwitasariWoro Supadmi
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2023-09-302023-09-3038441010.33759/jrki.v5i3.390ANALISA PERESEPAN DAN INTERAKSI KOMBINASI DUA MACAM ANTIBIOTIK INTRAVENA DI RUMAH SAKIT X TANGERANG SELATAN
https://jurnalfarmasi.or.id/index.php/jrki/article/view/391
<p><em>One of the mainstay drugs to treat infections is antimicrobials, including antibacterials/antibiotics, antifungals, antivirals and antiprotozoa. Antibiotics are drugs used in infections caused by bacteria. Antibiotics that are not used wisely can lead to resistance problems. Therefore, the use of antibiotics must follow a rational strategy of prescribing antibiotics. Irrational prescribing will increase the occurrence of drug side effects, drug interactions, medical costs and result in decreased patient compliance in taking drugs.</em></p> <p><em> The purpose of this study was to determine the pattern of prescribing combinations of intravenous antibiotics in one prescription sheet and their interactions.</em></p> <p><em>This research is a type of quantitative research, with descriptive methods and using retrospective data. The population in this study were all prescription sheets of inpatients who had been served at the X Hospital Pharmacy Installation for the period January 1 to March 31, 2021. The samples were all prescription sheets containing a combination of 2 (two) intravenous antibiotics (injection or infusion), all of which totaling 170 sheets.</em></p> <p><em> The results showed that there were more male patients than female patients, namely 52.3% with the largest age range between 46-55 years (29.41%). Of the 15 combinations of 2 (two) intravenous antibiotics, there were 6 combinations that had moderate pharmacodynamic interactions. Moderate interactions are clinically significant, usually avoided in combination or used only in special circumstances and with close monitoring of health workers. Of the 170 prescription sheets, 135 sheets (79.4%) were prescribed by internal medicine specialists. All intravenous antibiotics prescribed according to the X Hospital Formulary and the National Formulary.</em></p>
ArticlesAntibiotik, Interaksi Antibiotik intravenaAntibiotics, Intravenous Antibiotic InteractionInteraksi Antibiotik intravenaAntibiotikAntibioticsIntravenous Antibiotic InteractionChusun ChusunFitriani RetnoFauzi Yosep
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3035637210.33759/jrki.v5i3.391UJI SIFAT FISIKOKIMIA SEDIAAN EKSTRAK DAUN ALPUKAT (Persea americana Mill.) DENGAN VARIASI KONSENTRASI ASAM STEARAT
https://jurnalfarmasi.or.id/index.php/jrki/article/view/343
<p><em>The content of avocado leaf extract such as polyphenol, saponins, alkaloids, tannins, quercetin and flavonoids can be made anti-acne cream preparations. This study aims to determine the physicochemical properties of avocado leaf extract cream including organoleptic tests, homogeneity tests, pH tests, and spread diameter tests. The research method used is experimental research with a posttest only design methodology. Avocado leaf extract is made in cream preparations using a stearic acid base, namely with variations in concentrations of F1(10%), F2(12.5%), and F3(15%). Data analysis used the oneway ANOVA test and the LSD test to determine the difference between variations in stearic acid concentrations in avocado leaf extract cream. The results of the research on organoleptic and homogeneity tests were carried out descriptively showed that F1 was light green, had a distinctive smell of avocado leaf extract, slightly thick, F2 was green color and F3 was brownish green, both of which have a distinctive odor of avocado leaf extract and are thick. Homogeneity shows the three formulas are not homogeneous. The pH test results were F1(7.85±0.05), F2(6.97±0.03) and F3(6.79±0.02) which had significant differences. The spread diameter results are F1(5.70±0.53cm), F2(5.56±0.35cm) and F3(5.36±0.31cm) have no significant differences. Organoleptic, pH and spread diameter tests meet the requirements whereas homogeneity tests do not meet the requirements. The factor of adding avocado leaf extract to the preparation and the unstable mixing speed, because it is done manually using a mortar and stamper, affects the homogeneity of the cream produced.</em></p>
ArticlesDaun alpukat, krim, asam stearatDivia Tamara PutriFara Azzahra
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3045847210.33759/e37xby94GAMBARAN PENGADAAN OBAT E-PURCHASING UNTUK PASIEN PROGRAM RUJUK BALIK DI APOTEK KIMIA FARMA SAMARINDA
https://jurnalfarmasi.or.id/index.php/jrki/article/view/430
<p><em>Procurement plays an important role in the drug management cycle. Efforts to improve performance and efficiency in the drug procurement process, both for the JKN program and other health programs, procurement of drugs and medical devices must use an e-catalogue. The Refer Back Program (PRB) is BPJS Health's flagship program. Kimia Farma Pharmacy is a network pharmacy for the Refer Back Program. Kimia Farma Samarinda Pharmacy, in the procurement of PRB medicines has used e-purchasing and there are still obstacles found in the procurement system such as long lead times, unavailability of medicines at distributors, and price uniformity resulting in shortages of medicines which have a negative impact on the availability of medicines for patients referral program. This research aims to determine the management of drug availability using e-purchasing for referral program patients at Kimia Farma Samarinda Pharmacy. This research is qualitative research with a case study approach. The research was carried out by collecting primary data obtained through in-depth interviews with respondents who were deemed to know and be involved in the procurement and/or management process of medicines at Kimia Farma Pharmacy No. 114 Samarinda. Secondary data was obtained through observing documents related to drug procurement at Kimia Farma Pharmacy No. 114 Samarinda. Research results obtained from Kimia Farma Pharmacy No. 114 Samarinda show that the level of drug availability at Kimia Farma Pharmacy No. 114 Samarinda is still low (14.33%). The availability of PRB drugs in pharmacies is not sufficient to meet the needs of PRB participants. Drug vacancies are mostly caused by vacancies from distributors. To avoid patients not getting medicine, pharmacies borrow medicine from other Kimia Farma pharmacies or reduce the amount of medicine given to patients.</em></p>
ArticlesApotek, e-purchasing, Pengadaan, Program Rujuk BalikVita Hani IslamiAchmad Kadri AnsyoriRusdiati Helmidanora
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3047348610.33759/0whwam97GAMBARAN TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK EMPUNALA PERIODE MARET – MEI 2023
https://jurnalfarmasi.or.id/index.php/jrki/article/view/426
<p><em> Pharmaceutical services are health services that have an important role in realizing health quality. Pharmaceutical services apart from being a 2 demand for professionalism such as a factor that attracts consumers' interest in purchasing drugs at pharmacies in order to obtain patient satisfaction. The purpose of this study was to describe the level of patient satisfaction with pharmaceutical services at the Empunala Drug store and to improve the quality of pharmaceutical services at the Empunala Drug store. This Research is descriptive non-experimental with incidental sampling, data collection using a questionnaire. The results of the study on the level of patient satisfaction with pharmaceutical services at the Empunala Drug store period March until May 2023 concluded on the Reliability dimension is 76%, the Responsiveness dimension is 78%, the Assurance dimension is 78%, the Emphaty dimension is 77%, and the Tangible dimension is 80%. </em></p>
ArticlesPelayanan KefarmasianKepuasan KonsumenKonsumenAndri PriyoheriantoErna FitrianyDeny Budi LegowoM. Rizky Arif
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-312024-01-3115116210.33759/jrki.v6i1.426PROFIL PENGETAHUAN PENDUDUK TERHADAP OBAT GENERIK, MEREK DAN PATEN
https://jurnalfarmasi.or.id/index.php/jrki/article/view/339
<p><em>Republic of Indonesia Law Number 36 of 2009 states that medicine is a combination of ingredients, including biological products that are used to affect or investigate physiological systems or pathological conditions in the framework of establishing a diagnosis, prevention, cure, recovery, health promotion and contraception for humans. Generic drugs are drugs whose patents have expired, so all pharmaceutical companies can produce them without the need to pay for patents. Branded drugs are drugs that are marketed under certain trade names registered by the manufacturer. Patented drugs are drugs that have just been produced and marketed by a pharmaceutical company that has had patents for 20 years. The purpose of this study was to determine the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs. The descriptive observational research method by collecting primary data through questionnaires. The results of the study showed that 45 respondents (64.70%) had enough knowledge and 25 respondents (35.70%) had less knowledge. This shows that the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs is considered quite good. The conclusion of this study is that the population's knowledge profile of generic drugs, branded drugs, and patented drugs is included in the sufficient category, namely 64.70%. </em></p>
ArticlesKnowledge, Generic Drugs, Brand Drugs, and Patent DrugsMexsi Mutia RissaNabila Ayu Puspita
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-01-252023-01-25566710.33759/jrki.v5i1.339KARAKTERISASI DAN SKRINING FITOKIMIA BUAH LABU KUNING (Cucurbita moschata Duch.)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/420
<p><em>Pumpkin (Cucurbita moschata Duch.) is one of the plants that contain carotenoids, water-soluble vitamins, phenolics, flavonoids polysaccharides, mineral salts. Pumpkin is a vegetable that has many health benefits. Empirically, the pulp is used to treat diabetes, hypertension, tumors, immunomodulators and antibacterials. The benefits of a natural material with medicinal properties need to be proven scientifically through research. As a first step, characterization of simplisia and ethanol extract of pumpkin fruit and secondary metabolite content were carried out. This study aims to determine the characteristics of simplisia and pumpkin fruit flesh extract and its secondary metabolite content. Characterization includes specific and non-specific parameters. Pumpkin fruit was extracted by maceration with 70% ethanol and obtained an extract yield of 29.68%. Specific characterization results include organoleptic observations in the form of thick blackish brown extract, bitter taste, and distinctive smell. Organoleptic simplicia simplicial piece, odorless, yellow, and bitter taste. The average level of soluble compounds in water extract is 47.33% and simplisia is 22%, while the average soluble compound in ethanol extract is 51.77% and simplisia is 31.33%. Non-specific characterization results include the average total ash content of extracts of 6.52% and simplisia of 8.33%, acid insoluble ash content test averaged 0.31% extracts and 0.22% simplisia. The average water content was 17.55%. The average specific gravity of the extract was 1.02 g/mL and the results of the total microbial contamination in the extract were 4.2 × 10<sup>3</sup> colonies/g and simplisia were 4.6 x 10<sup>3</sup> and the yeast mold number in the extract was 1.3 × 10<sup>2</sup> colonies/g and simplisia was 1.7 × 10<sup>2</sup> colonies/g. Pumpkin fruit extract and simplisia contain secondary metabolites including alkaloids, flavonoids, saponins, and terpenoids.</em></p>
ArticlesCucurbita moschata Duch, simplisia, ekstrak, karakterisasiHariyadi BudimanRisa SupriningrumReksi Sundu
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2024-01-292024-01-29163610.33759/jrki.v6i1.420RENDEMEN EKSTRAK ETANOL HERBA RUMPUT AKAR WANGI (Polygala paniculata L) PADA PERBANDINGAN KONSENTRASI PELARUT
https://jurnalfarmasi.or.id/index.php/jrki/article/view/418
<p><em>Rumput akar wangi (Polygala paniculata (L)) belongs to the Polygalaceae family. One of the extract yields is influenced by solvent concentration. The aim of the research is to determine the effect of variations in concentration on the yield of Polygala paniculata extract and the groups of compounds in the extract. This research includes determination, collection, and plant preparation, processing of Polygala paniculata simplicia, extraction, screening, and determination of yield. In this study, 50 grams of Polygala paniculata powder were extracted with different solvent concentrations, namely 70% and 95% ethanol using the maceration method. Replication was carried out on each solvent three times. Data were analyzed using descriptive methods and processed using SPSS (Statistical Product and Service Solutions) tools.</em><em> </em><em>The results of phytochemical screening showed that the extract contained flavonoids, tannins, saponins, and terpenoids. The calculation results of the ethanol extract of Polygala paniculata were 70% ethanol (17.77% ± 1.34) and 95% ethanol (12.59% ± 0.86). The SPSS test results on the Independent Samples Test show that there is a significant difference (p < 0.05). </em><em>The highest yield of </em><em>Polygala paniculata </em><em>extract was obtained using 70% ethanol for filtration</em>.</p>
ArticlesRendemen, Polygala paniculata, etanol 70%, etanol 95%Anugerah Riska PradanaHendra WahyudiDwi Lestari
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
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2023-09-302023-09-3037338310.33759/jrki.v5i3.418UJI EFEK ANTIPIRETIK EKSTRAK ETANOL BIJI KORO BENGUK (Mucuna pruriens L.) DENGAN METODE SOKHLETASI PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/417
<p><em>Mucuna pruriens L</em><em> is a plant that lives in a tropical climate and is widely found in Indonesia. Public knowledge on how to use velvet bean is still limited. </em><em>Mucuna pruriens L</em><em> plants have benefits such as antibacterial, gout, cancer, diabetes, kidney stones. The purpose of this study was to determine the effectiveness and antipyretic effect of </em><em>Mucuna pruriens L</em><em> ethanol extract. This study used the socleation method as an extraction method. Velvet </em><em>Mucuna pruriens L</em><em> </em><em> ethanol extract was given orally to male white rats. The administration of extracts was divided into 5 groups, namely group 1 given CMC-Na as a negative control, group II paracetamol 45 mg / kg BB, group III 200 mg / KgBB and group IV 300 mg / KgBB and group V 400 mg / KgBB. The body temperature of the rats was measured at intervals of 30 minutes to 150 minutes when they were given the test substance orally. Based on research analysis showed that at a dose of</em><em> 400 mg / KgBB m</em><em>had a comparable entipyretic effect strength in positive controls</em><em>. </em><em>Therefore</em><em>, </em><em>Mucuna pruriens L</em><em> have potential as antipyretic drugs</em>.</p>
ArticlesAnti PiretikKoro BengukSokhletasiFarmasetika dan Teknologi FarmasiAlifa Ayuanti Santosa PutriEka Wisnu Kusuma
Copyright (c) 2024 Jurnal Riset Kefarmasian Indonesia
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2024-01-302024-01-309711010.33759/jrki.v6i1.417EFEK LARVASIDA EKSTRAK ETANOL DAUN BINTANGUR (Chalophyllum inophyllum L.) TERHADAP MORTALITAS LARVA NYAMUK AIR KOTOR (Culex sp.)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/350
<p><em> </em><em>The Bintangur plant is a plant that can often be found around the house, its existence as a plant makes its properties less known to the public, all parts of this plant are known to be very useful for various pharmacological effects. Various efforts to prevent diseases transmitted by Culex sp. one of them uses larvicides, so an alternative larvicide from natural ingredients is needed, namely Bintangur. The purpose of this study was to determine the activity of the ethanol extract of Bintangur leaves in killing Culex sp larvae with the control being the larvae that were not given the ethanol extract of Bintangur leaves. The type of research on the activity test of the Bintangur leaf ethanol extract used an experimental research type with a true experiment design with a posttest only control group design. The results showed that the ethanol extract of Bintangur leaves (Chalophyllum Inophyllum L.) was active in killing Culex sp. larvae. with the results of the Reed and Muench test with an LC50 value of 281.84 ppm</em></p>
ArticlesBintangurLarvasidaLC50Ahmad Purnawarman FaisalAdhisty NurpermatasariPratiwi Rukmana Nasution
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-202023-05-2021622710.33759/jrki.v5i2.350IDENTIFIKASI SENYAWA ANTIOKSIDAN DARI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius) DENGAN METODE 2,2-DIPHENYL-1-PICRYL-HYDRAZYL ( DPPH )
https://jurnalfarmasi.or.id/index.php/jrki/article/view/360
<p><em>Pandan wangi</em> <em>(Pandanus amaryllifolius) is one type of monocotyledonous in the Pandanaceae family that has leaves with a characteristic fragrant aroma. There is a chemical content in the leaves of pandan wangi (Pandanus amaryllifolius) namely alkaloids, flavonoids, saponins, tannins, and polyphenols that can be used as natural antioxidants. This study aims to identify the presence of antioxidant compounds in ethanol extract of pandan wangi leaves (Pandanus amaryllifolius). The research method is an experimental method. The extraction process by maceration and antioxidant testing of pandan wangi leaves (Pandanus amaryllifolius) ethanol extract used the DPPH method where Vitamin C being a positive control, and IC50 value as a parameter. The results stated that ethanol extract of Pandan wangi leaves (Pandanus amaryllifolius) has antioxidant activities that are classified as effective with an IC<sub>50 </sub>value of 27.65 ppm, while Vitamin C as positive control is classified as an effective antioxidant with an IC<sub>50</sub> value of 2.58 ppm.</em> <em>Based on the results of the research that has been done, it can be concluded that the ethanol extract of Pandan Wangi leaves has a good antioxidant content in counteracting free radicals</em><em>.</em></p>
ArticlesAntioksidan, Daun Pandan Wangi, DPPH, IC50A Rufaidah HasharyUtami Putri DamayantiRusdiaman RusdiamanAn Nisaa Nurzak
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2023-05-202023-05-2020421510.33759/jrki.v5i2.360FORMULASI LIP BALM EKSTRAK LIDAH BUAYA (ALOE VERA) DAN BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI PELEMBAB BIBIR
https://jurnalfarmasi.or.id/index.php/jrki/article/view/394
<p><em> </em><em>Lip balm is a cosmetic preparation with main components such as waxes, fats and oils. The purpose of this study was to determine whether Aloe vera and red dragon fruit extracts could be formulated as moisturizers and natural dyes in lip balm preparations. The study was carried out experimentally, including the formulation of preparations with concentrations of Aloe Vera extract 3%, 6%, 10%, and Red Dragon Fruit extract 3%, 5%, 7%. Examination of the physical quality of the preparation, namely homogeneity test, stability during 28 days of storage at room temperature, melting point, pH, and preference test. The results showed that (F1) with a concentration of 3% aloe vera and 3% red dragon fruit met the requirements for homogeneity, melting point, pH, and stability tests, on (F2) with a concentration of 6% aloe vera and 5% red dragon fruit does not meet the requirements of the pH test, but meets the requirements of the homogeneity test, melting point test, and stability test. Whereas for (F3) with a concentration of 10% aloe vera and 7% red dragon fruit did not meet the homogeneity and pH test requirements, but met the melting point and stability test requirements. It can be concluded that Aloe Vera Extract and Red Dragon Fruit can be formulated into lip balm dosage forms. Differences in concentration variations can affect the moisture on the skin and the color of the preparation.</em></p>
Articleslidah buayanaga merahlip balmAntetti Tampubolon
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-06-012023-06-0131032110.33759/jrki.v5i2.394ANALISIS RESEP TIDAK TERLAYANI PASIEN RAWAT JALAN DI INSTALASI FARMASI RSU X JAKARTA
https://jurnalfarmasi.or.id/index.php/jrki/article/view/374
<p><em>Pharmacy service is inseparable from health service system of a hospital. The service of pharmacy unit shall be a priority because an effective and efficient service will affect in the fulfillment of prescriptions. Furthermore, the management on the pharmaceutical stock will influence the revenue of the hospital (part of revenue center). The purpose of this research is to find out the percentage of unfilled prescriptions of outpatients from many different units, its reasons, and Therapeutic Class of unserved drug items. The research applies descriptive method using prospective data i.e. 25,259 R/ sheets of prescriptions obtained by total sampling technique. The research was conducted in three months from February to April 2021. The result of the research shows that there are unfilled 467 R/ prescriptions due to several factors, such as the drugs are not listed in the formularies, the drugs are out of stock, and the prescribed or patient-requested drugs are not covered by the insurance. Internal medicine unit has the most unfilled prescriptions (160 out of 467). The main reason is the drugs are out of stock (133 out of 467). Medicines for Gastritic, Respiratory, Heart Diseases and Allergicare the top lists in the Therapeutic Class, which is in accordance with data showing that Intenal Medicine, Emergency Department dan General Practisioners, Pulmonary, Dermatology and Venereology, and Obstetrics and Gynecology are the top 5 polyclinics with the number of unserved prescriptions due to out of stock.</em></p>
ArticlesInstalasi farmasi, kekosongan obat, resep tidak terlayani, Therapeutic ClassIka AgustinaFarida TuahunsCharles CharlesArfie Nur Adina
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-212023-05-2129930910.33759/jrki.v5i2.374IDENTIFIKASI JENIS SAPONIN DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL KULIT BATANG SEKILANG (Embelia borneensis Scheff.) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 9027 DAN Streptococcus mutans ATCC 25175
https://jurnalfarmasi.or.id/index.php/jrki/article/view/368
<p><em> Sekilang stem bark (Embelia borneensis Scheff.) contains secondary metabolites, such as alkaloids, flavonoids, tannins, and saponins. Saponin compounds are divided into two types, namely steroids and triterpenoids which have the ability as antibacterial, antifungal, antidiabetic and expectorant. The purpose of this study was to determine the type of saponin and to determine the antibacterial activity of the methanolic extract of sekilang bark against Streptococcus mutans and Pseudomonas aeruginosa bacteria. The research stages included plant determination, sample collection, simplicia making, extract preparation by maceration method using methanol, phytochemical screening, identification of saponins and antibacterial activity test of methanol extract of sekilang stem bark by disc diffusion method against Streptococcus mutans and Pseudomonas aeruginosa bacteria with a concentration of 15% , 20%, 25%, 30%, and 35%. The results showed that the methanol extract of sekilang stem bark contained triterpenoid saponins and had antibacterial activity against Streptococcus mutans bacteria at concentrations of 15%, 20%, 25%, 30%, and 35% with an inhibition zone formed of 7.65 mm, 7.89 mm, 7.67 mm, 7.98 mm, and 7.13 mm the criteria for antibacterial strength were categorized as moderate. The methanolic extract of the bark of sekilang did not show antibacterial activity against Pseudomonas aeruginosa bacteria, because there was no inhibition zone formed around the paper disc. The positive control used was amoxicillin 0.1% and the negative control used 1% DMSO.</em></p>
Articlesjenis saponin, antibakteri, Embelia borneensis, Streptococcus mutans, Pseudomonas aeruginosaMaria F.K. HayonRisa SupriningrumNurul Fatimah
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-202023-05-2025827210.33759/jrki.v5i2.368UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR MINYAK ATSIRI KULIT BUAH JERUK BALI (Citrus maxima)
https://jurnalfarmasi.or.id/index.php/jrki/article/view/355
<p><em> </em><em>Pomelofruit</em><em> (Citrus maxima) has several chemical compounds, one of which is essential oil, 6.68g of essential oil was found in the peel of the </em><em>pomelofruit</em><em> (Citrus maxima) which has an active compound, namely limonene (94.96%). The essential oil provided strong antibacterial activity against S. aureus isolates. The purpose of the study was to formulate the essential oil of </em><em>pomelofruit </em><em>peel (Citrus maxima) into liquid soap preparations that met physical stability and to test the antibacterial activity of liquid soap preparations of </em><em>pomelofruit</em><em> (Citrus maxima) peel essential oil against S. aureus bacteria. The method used in testing the stability of liquid soap preparations is cycling test and in the antibacterial activity test using the Disk diffusion method. The results obtained that the essential oil of </em><em>pomelofruit</em><em> peel (Citrus maxima) can be formulated in the form of liquid soap because it meets the physical stability test, namely before and after the cycling test and activity tests. antibacterial against S. aureus. at 1% concentration of 18.9mm (strong), 3% of 20.4mm (very strong), and 5% of 21.1mm (very strong). Based on this, the essential oil of </em><em>pomelofruit</em><em> peel (Citrus maxima) can be made into liquid soap preparations that meet the physical stability test and have antibacterial activity in very strong category at a concentration of 5% in inhibiting the growth of S. aureus bacteria</em><em>.</em></p>
ArticlesKulit Buah Jeruk BaliMinyak AtsiriAndi Juaella YustisiSri WahyuningsihNielma Auliah
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-202023-05-2022824410.33759/jrki.v5i2.355UJI ANTIOKSIDAN EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) LERENG GUNUNG ARGOPURA KABUPATEN JEMBER PADA BERBAGAI KONDISI PENYANGRAIAN
https://jurnalfarmasi.or.id/index.php/jrki/article/view/381
<p><em>Coffee (Coffea arabica L.) is a plant which has been cultivated in Indonesia and it is one of natural source of antioxidants. The main bioactive component which contain antioxidant properties is chlorogenic acid. The roasting process can cause chlorogenic acid in coffee beans to decrease as the temperature increases and the length of roasting, so the way coffee is served as a source of antioxidants which may need to be considered. The purpose of this study was to determine the group of compounds and antioxidant activity contained in Arabica coffee beans obtained from the slopes of Mount Argopura at various conditions of roasting. The samples of Arabica coffee beans each done roasting in advance at a temperature of 160°C - 180°C; 190°C - 210°C; and 220°C - 240°C before it is milled. The used of extraction method is maceration using 80% ethanol solvent. Antioxidant activity testing was done by DPPH method. Antioxidant activity is expressed based on the IC<sub>50</sub> value (Inhibitor Concentration 50%). The highest value of antioxidant activity was obtained from Arabica coffee beans roasted at a moderate temperature with a value </em><em>of IC<sub>50</sub> 26.41 ± 0.182 ppm. The result of the T-test obtained a sig value < 0.05 which indicates a difference in the antioxidant activity produced by the extract of Arabica coffee beans at various conditions of roasting.</em></p>
ArticlesAktivitas Antioksidan; Biji Kopi; Coffea arabica; Metode DPPHIski Weni PebriartiAgustin Nourma Diana
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-212023-05-2128429810.33759/jrki.v5i2.381POTENSI ANTIBAKTERI EKSTRAK ETANOL DAUN SELUTUI PUKA (Tabernaemontana macrocarpa Jack.) TERHADAP BAKTERI Streptococcus mutans DAN Porphyromonas gingivalis
https://jurnalfarmasi.or.id/index.php/jrki/article/view/372
<p><em>The Dayak people in West Kutai, East Kalimantan use selutui puka leaves for the treatment of toothache and canker sores. Bacteria that often cause infections in the oral cavity are Streptococcus mutans and Porphyromonas gingivalis. The aim of this study was to determine the activity of the ethanol extract of selutui puka leaves as an antibacterial against Streptococcus mutans and Porphyromonas gingivalis. The research phase involved collecting samples, plant determination, preparing simplicia, preparing extracts and testing antibacterial activity using the paper disc diffusion method with extract concentrations of 15%, 30% and 45%, DMSO negative control 1%, positive control Ciprofloxacin 0.1%. The results showed that the average diameter of the inhibition zone for Streptococcus mutans at an extract concentration of 15% was 17.70 mm (strong), 30% was 19.43 mm (strong), and 45% was 23.60 mm (very strong). ) and against Porphyromonas gingivalis bacteria at an extract concentration of 15% of 17.43 mm (strong), 30% of 23.33 mm (very strong), and 45% of 26.03 mm (very strong).</em></p>
ArticlesDaun, Selutui Puka, Antibakteri, Streptococcus mutans, Porphyromonas gingivalispharmacySheila Dwi SabatiniFitri HandayaniReksi Sundu
Copyright (c) 2023 Jurnal Riset Kefarmasian Indonesia
2023-05-202023-05-2027328310.33759/jrki.v5i2.372