Jurnal Riset Kefarmasian Indonesia https://jurnalfarmasi.or.id/index.php/jrki <p>"<strong>The Jurnal Riset Kefarmasian Indonesia</strong>" &nbsp;is Journal of Pharmaceutical and Health Science published by APDFI Organization (Asosiasi Pendidikan Diploma Farmasi Indonesia) covering Organization of Pharmacy, Medical, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Physical Chemistry, Biology, Microbiology, Tissue Culture, Botany and animals related to pharmaceutical products, Health Analyst, Nutrition and Public Health.</p> <pre id="tw-target-text" class="tw-data-text tw-ta tw-text-small" dir="ltr" data-placeholder="Translation">&nbsp;</pre> APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) en-US Jurnal Riset Kefarmasian Indonesia 2655-8289 LAJU FILTRASI GLOMERULUS PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK https://jurnalfarmasi.or.id/index.php/jrki/article/view/179 <p><em>Diabetes Mellitus (DM) Type II is a group of metabolic diseases with hyperglycemia characteristics. The use of oral hypoglycemic drugs (OHO) lasts for a relatively long time. Most of the OHO is excreted through the kidneys. This study aims to determine the Glomerulus Filtration Rate (GFR) of type 2 DM patients who use OHO at the "X" Hospital, District of Demak. This study is an observational descriptive study using retrospective data obtained from medical record data (RM) of outpatient JKN participants with type 2 DM for the period October-December 2020. Inclusion criteria were patients who received OHO for at least one year with or without comorbidities, aged 36-65 years, and had a serum creatinine test. Patients receiving combination therapy with insulin were excluded. LFG is calculated using the Cockroft-Gault formula. From 82 patients, 52 patients (62.2%) were female, 74 patients (90.2%) were more than 45 years old. Patients who consumed OHO for more than 2 years were 47 (57.3%). Patients without comorbidities were 62 (75.7%) people. Patients who experienced a decrease in GFR in the moderate category (stage 3) as many as 24 people (29.3%), a decrease in GFR in the severe category (stage 4) as many as 5 people (6.1%) and 1 person (1.2%) experienced End Stage Renal Disease.</em></p> Fef Rukminingsih Mei Widiastuti ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-28 2021-09-28 3 3 152 161 10.33759/jrki.v3i3.179 UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN MANGGA KASTURI (Mangifera casturi Kosterm.) https://jurnalfarmasi.or.id/index.php/jrki/article/view/169 <p><em>Mangga Kasturi (Mangifera casturi Kosterm.) is one of the plants in Indonesia that has potential as an antioxidant. The purpose of this study was to determine the IC50 value and antioxidant potential of the ethanol extract of mangga kasturi leaves (Mangifera casturi Kosterm.). The ethanol extract of mangga kasturi leaves (Mangifera casturi Kosterm.) was extracted using maceration with 96% ethanol as solvent. The antioxidant activity test was carried out using the DPPH (1,1-Diphenyl-2-Picrylhydrazil) method using a UV-Vis spectrophotometer and vitamin C as a comparison. The results of phytochemical screening tests on ethanol extracts showed positive secondary metabolites such as alkaloids, flavonoids, tannins, and quinones. Testing the ethanol extract of Mangga Kasturi leaves (Mangifera casturi Kosterm.) with the DPPH method showed that the ethanol extract had an antioxidant activity with an IC50 value of 83.61 ppm in the strong category of antioxidant potential.</em></p> Dwi Lestari Muthia Dwi MA Jati Pratiwi Lidya Handoko Saputri ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-28 2021-09-28 3 3 162 173 10.33759/jrki.v3i3.169 PENGARUH TERAPI FARMAKOLOGI DAN NON-FARMAKOLOGI TERHADAP PENURUNAN NYERI MENSTRUASI PADA MAHASISWI FAKULTAS FARMASI UNIVERSITAS BHAKTI KENCANA BANDUNG https://jurnalfarmasi.or.id/index.php/jrki/article/view/156 <p><em>Menstrual pain is a problem that women often complain about in their teens. Menstrual pain (dysmenorrhea) is pain before or during menstruation in the lower abdomen due to uterine cramps. The prevalence of dysmenorrhea in Indonesia is 54% primary dysmenorrhea and 9% secondary dysmenorrhea. Due to the severe pain that is felt during menstruation, 10% of teenage girls are absent from school and work for 3 days each month. This study aims to determine the effect of pharmacological &amp; non-pharmacological therapy on reducing menstrual pain in adolescents. This research is an experimental research with one group pretest-post test design. The research sample used purposive sampling method, with a sample of 76 respondents. Data were analyzed using the Wilcoxon Signed Rank Test &amp; chi-square test. The results showed that the Wilcoxon test with the results of Sig. 0.000&lt;0.05, meaning that there is a difference in the intensity of menstrual pain before &amp; after therapy. So it can be concluded that there is an effect of pharmacological and non-pharmacological therapy on decreasing the intensity of menstrual pain. For the relationship of non-pharmacological therapy Chi-Square test results have a value of Sig. 0.514&gt;0.05, meaning that there is no significant relationship to the intensity of menstrual pain. For the relationship between pharmacological therapy, the results of Sig. 0.019&lt;0.05, meaning that there is a significant relationship with the intensity of menstrual pain in adolescent girls at Bhakti Kencana University, Bandung.</em></p> Ani Anggriani Yani Mulyani Lili Dinda Pratiwi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-29 2021-09-29 3 3 174 188 10.33759/jrki.v3i3.156 GAMBARAN PENGGUNAAN TERAPI GEA (GASTROENTERITIS ) PADA PASIEN ANAK DI RSUD BATARA SIANG PANGKEP SULSEL https://jurnalfarmasi.or.id/index.php/jrki/article/view/137 <p><em>GEA (Gastroenteritis) or diarrhea is a disease caused by digestive tract disorders that are infected by bacteria. Treatment of early diarrhea, especially the choice of initial therapy, greatly affects the success of providing appropriate and appropriate therapy. This study aims to determine the rationality of therapy in pediatric patients at Batara Siang Pangkep Regional Hospital, South Sulawesi City. This study is a non-experimental study with a retrospective descriptive evaluation study using patient medical records. The samples that met the inclusion criteria were 65 patients. Acute diarrhea was mostly found in men as many as 38 patients (58%) while for women as many as 27 patients (42%). Characteristics of age 1-3 years (82%). The result showed that there are 3 therapeutic regimen in pediatric patient namely cotrimoxazole,electrolit, and zinc. So from these data meet the standards of management of diarrheal disease in children.</em></p> Dwi Fitrah Wahyuni Riska Riska ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-29 2021-09-29 3 3 189 198 10.33759/jrki.v3i3.137 ANALISIS KANDUNGAN PEMANIS BUATAN SIKLAMAT PADA SIRUP YANG BEREDAR DIPASAR BESAR MALANG SECARA KUANTITATIF MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS https://jurnalfarmasi.or.id/index.php/jrki/article/view/184 <p><em>Sweeteners are chemical compounds that are often added and used for industrial food processing products as well as beverages and foods, sweeteners consist of natural sweeteners and synthetic sweeteners, one of the synthetic sweeteners is sodium cyclamate. This study aims to identify and determine the level of sodium cyclamate in syrup by UV spectrophotometry method and to determine the level of sodium cyclamate in syrup is still safe for consumption. The type of research is experimental and descriptive. The research sample used is syrup which is sold in the big market of Malang City. The method used for the determination of sodium cyclamate levels was done by UV spectrophotometry whose absorption was measured at a maximum wavelength of 314 nm. The results of the quantitative analysis showed that there were positive samples containing sodium cyclamate, namely sample 1, sample 2 and sample 3. The assay results in sample 1 were 238.78 mg/kg, sample 2 was 239.65 mg/kg and sample 3 was 241.39 mg/kg. Of the three samples tested for levels of cyclamate in syrup sold in the big market in Malang City, they still meet the requirements set by the head of the Food and Drug Supervisory Agency.</em></p> Lukky Jayadi Maritha Hernaningsih ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-29 2021-09-29 3 3 199 210 10.33759/jrki.v3i3.184 PENGARUH PENAMBAHAN POLIETILEN GLIKOL 6000 PADA TABLET IBUPROFEN DISPERSI PADAT TERHADAP ABSORBSI IBUPROFEN SECARA IN SITU https://jurnalfarmasi.or.id/index.php/jrki/article/view/167 <p><em>Drug absorption can be decided by various methods, namely in vitro methods, in situ methods, and in vivo methods. The in situ method is a procedure that is very close to the in vivo method. The aim of this study was to identify the effect of accumulation of polyethylene glycol 6000 (PEG 6000) on solid dispersion of ibuprofen tablets on the in-situ absorption of the drug. This research was conducted through an experiment to determine the effect of adding polyethylene glycol 6000 to the absorption of ibuprofen in situ by flowing the solution from solid dispersion ibuprofen tablets, solutions from generic ibuprofen tablets and standard ibuprofen solutions. The solid dispersion system was carried out by melting ibuprofen and polyethylene glycol 6000 in a ratio of 1:05. The drug solution was flowed through the lumen of the small intestine of male rats. Unabsorbed ibuprofen was measured by an ultraviolet spectrophotometer at a wavelength of 225.5 nm. Next, the absorbed level of ibuprofen was calculated. The results showed that ibuprofen from solid dispersion tablets was absorbed more than ibuprofen from generic tablets and standard ibuprofen. It can be concluded that polyethylene glycol 6000 has an effect on the absorption of ibuprofen in situ.</em></p> Antetti Tampubolon ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2021-09-30 2021-09-30 3 3 211 222 10.33759/jrki.v3i3.167