PEMANFAATAN POTENSI LIMBAH KULIT BAWANG MERAH (Allium Cepa. L) SEBAGAI SEDIAAN GEL HAND SANITIZER
The increased health problems caused by microorganisms at the hands, hand sanitizer gel as the way out to maintained health and hand hygiene because it is more practical and easy to carry. The purpose of this study was to make formulations of gel with physically stable and had inhibitory activity against the Staphylococcus aureus bacteria. In this study three formulations were made with a ratio of Hydroxy ethyl selilulose 0.5% (F1), 1% (F2) and 2% (F3) then physical stability testing included organoleptic, homogeneity, pH and dispersion before and after accelerated storage, then antimicrobial activity by sump method. Organoleptic test showed there is no color, smell and texture changes. The results of the homogenety test, formula with concentration of Hydroxy ethyl cellulose 1% and 2% is homogeneous. The pH test results showed that the gel preparation did not change pH. Dispersing test showed concentration hydroxyethyl cellulose 1% has the highest dispersion value. but statistical paired T test results showed that the dispersion before and after storage was accelerated significantly different 0.043 (p <0.05), but still in accordance with the range of dispersion specifications for a good semisolid preparation.The MIC test results showed Formulation F1, F2 and F3 ethanol extract red onion skin gel are strong inhibitory effect, ethanol extract of red onion skin gel F1 inhibitory zone is 16mm, F2 and F3 had the same inhibitory zone is 14.33. It can be concluded F2 has the best physical stability, but F1 is the most effective to inhibit Staphylococcus aureus.
Dirjen POM. 1995. Farmakope Indonesia, edisi IV, Departemen Kesehatan Republik Indonesia, Jakarta.
Hänninen, O., Kaartinen, K., Rauma, A. L., Nenonen, M., Törrönen, R., Häkkinen, S., ... & Laakso, J. (2000). Antioxidants in vegan diet and rheumatic disorders. Toxicology, 155(1-3), 45-53.
Lanzotti, V., Barile, E., Antignani, V., Bonanomi, G., & Scala, F. (2012). Antifungal saponins from bulbs of garlic, Allium sativum L. var. Voghiera. Phytochemistry, 78, 126-134.
Fitri, L. (2010). Kemampuan daya hambat beberapa macam sabun Antiseptik terhadap pertumbuhan Staphylococcus aureus dan Escherichia coli. Jurnal Biologi Edukasi, 2(2), 33-39.
Misna, M., & Diana, K. (2016). Aktivitas antibakteri ekstrak kulit bawang merah (Allium cepa l.) terhadap bakteri Staphylococcus aureus. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2(2), 138-144.
Reynolds, S.A., Levy, F., Walker, E.S.,, Anti acne Alert. (2006). Emerging Infectious Diseases. 12(3), 527-529.
Sadeghi, M., Zolfaghari, B., Senatore, M., & Lanzotti, V. (2013). Spirostane, furostane and cholestane saponins from Persian leek with antifungal activity. Food chemistry, 141(2), 1512-1521.
Shu, M. (2013). Formulasi sediaan gel hand Sanitizer dengan bahan aktif Triklosan 0, 5% dan 1%. Calyptra, 2(1), 1-14.
Wu, Y., He, Y., & Ge, X. (2011). Functional characterization of the recombinant antimicrobial peptide Trx-Ace-AMP1 and its application on the control of tomato early blight disease. Applied microbiology and biotechnology, 90(4), 1303-1310.
World Health Organization. (2005). Guidelines for Hand Hygiene in Health-Care, Global Patient Safety Challenge, USA, 12-23.
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