Jurnal Riset Kefarmasian Indonesia http://jurnalfarmasi.or.id/index.php/jrki <p>"<strong>The Jurnal Riset Kefarmasian Indonesia</strong>" &nbsp;is Journal of Pharmaceutical and Health Science published by APDFI Organization (Asosiasi Pendidikan Diploma Farmasi Indonesia) covering Organization of Pharmacy, Medical, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Physical Chemistry, Biology, Microbiology, Tissue Culture, Botany and animals related to pharmaceutical products, Health Analyst, Nutrition and Public Health.</p> <pre id="tw-target-text" class="tw-data-text tw-ta tw-text-small" dir="ltr" data-placeholder="Translation">&nbsp;</pre> en-US fahmipomo@gmail.com (Supomo, S.Si., M.Si., Apt.) jurnal.apdfi@gmail.com (Agus Trimanto,S.I.Pust) Fri, 22 Jan 2021 18:34:07 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 POTENSI INTERAKSI OBAT AMLODIPIN PADA PASIEN HIPERTENSI DISALAH SATU PUSKESMAS KABUPATEN SUMEDANG http://jurnalfarmasi.or.id/index.php/jrki/article/view/108 <p><em>Hypertension is still a main health problem in indonesia, the purpose of this research is to know the profile of the antihypertensive agent and the interaction potency of the drugs and the relation between the amount of the drugs towards the interaction occurrence in public health centre of sukasari in district of sumedang by the period of July-December 2019. This was observational research with descriptive method. The data collection was performed using drug interaction checker software. There are data of 112 patients. The analysis was performed quantitatively and qualitatively. the result shows the interaction occurrence are happened to woman with percentage of 90% in age group of 65-74 years (30%). Hypertension stage 2 is the most occurred (69%), also there are 82 (73%) patients with potentially might have interaction, meanwhile from all medicines, there are 116 occurrence of interatction might happen. The most interaction occurred happen to amlodipin and hycrochlorothiazide (41%), with pharmacodynamic interaction of 62% and minor severity of 62%.</em></p> Ani Anggriani, Eva Kusumahati, Irfan Hilmi Mutazam ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/108 Tue, 05 Jan 2021 05:39:55 +0000 ANALISIS PEWARNA RHODAMIN B DAN PENGAWET NATRIUM BENZOAT PADA SAUS TOMAT YANG DIPERDAGANGKAN DI PASAR BESAR TRADISIONAL KOTA MALANG http://jurnalfarmasi.or.id/index.php/jrki/article/view/105 <p><em>One type of food product that usually uses food additives in the form of coloring agents and preservatives is sauce. Tomato sauce is a pasta-shaped product with a distinctive aroma of tomatoes. The number of sauces containing hazardous substances circulating in the community because of the increasing number of emerging home industries that do not use the correct rules for making sauces. The purpose of this study is to analyze the content of Rodhamin B coloring agents and levels of preservative Sodium Benzoate in tomato sauce traded in the Traditional Market of Malang City. The design of this study is observational, which is to dig data about the quality of tomato sauce in Malang City's Big Market by looking at the content of Rhodamin B Content and Sodium Benzoate. From the results of the study note that all tomato sauce samples do not contain Rodhamin B, while 2 of the 3 samples contain sodium benzoate preservative which exceeds the maximum threshold of 1gr / kg. Therefore, the public must be careful in buying tomato sauce products or other products that can be harmful to health.</em></p> Orchidosia Zukhruffin Jannah, Komang Suwita, Lukky Jayadi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/105 Tue, 05 Jan 2021 09:00:34 +0000 UJI KANDUNGAN TIMBAL (Pb) PADA GORENGAN YANG DIJUAL DI PINGGIR JALAN SEPANJANG PANTAI GANDORIAH PARIAMAN SECARA SPEKTROFOTOMETRI SERAPAN ATOM http://jurnalfarmasi.or.id/index.php/jrki/article/view/118 <p><em>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Lead is one of the heavy metal elements found in the air pollution which is produced together with motor vehicle fumes. Lead can cause various disorders in human body such as anemia, neurological damage, deformities and body functions, dental caries, impaired kidney function, effects on the heart and infertility. Lead </em><em>can enter the human body through inhaled air, through the skin and ingested with food. The purpose of this study was to determine the lead content in fried foods (fried sala, fried crab, fried shrimp and fried fish) sale around of Gandoriah Beach, Pariaman. This research was conducted at Baristand Laboratory (Research and Standarirdization Industry Center) Padang from February until March 2020. This study was conducted on 4 samples taken randomly from the total population. The instrument used was atomic absorption spectrophotometry (AAS). The results of 4 samples showed that the lead content in fried sala was 0.1618 mg/kg, with a maximum SNI limit is 0.3 mg/kg, fried crab was 0.4025 mg/kg with a maximum SNI limit is 0,5 mg/kg, fried shrimp was 0.4377 mg/kg with a maximum SNI limit is 0.5 mg/kg, fried fish was 0.2331 mg/kg with an SNI maximum limit is 0.3 mg/kg. Based on the results of this study, it can be concluded all samples contain lead but the level is still below of maximum limit of SNI&nbsp;</em><em>7387-2009.</em></p> Mega Yulia, Dani Syahrianti, Rahma Yulis ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/118 Sat, 09 Jan 2021 15:08:27 +0000 ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DI RUANG THERESIA RUMAH SAKIT ST. ELISABETH SEMARANG DENGAN METODE ATC/DDD http://jurnalfarmasi.or.id/index.php/jrki/article/view/110 <p><em>The high incidence of infectious diseases causes the use of antibiotics to increase. Inappropriate use of antibiotics will lead to resistance. Infectious diseases are included in the top 10 diseases in pediatric patients at St. Elisabeth Hospital.Semarang. This study aims to evaluate the use of antibiotics in pediatric patients in the Theresia </em><em>ward</em><em> of St. Elisabeth</em><em> Hospital</em><em> Semarang. This research is a descriptive observational study using retrospective data. Data were taken from medical records of pediatric patients in the Theresia </em><em>ward</em><em> at St. Elisabeth </em><em>Hospital </em><em>Semarang, aged 6 months - 14 years, the use of antibiotic therapy during the period October - December 2019. The data obtained were analyzed by calculating the quantity of antibiotic use using the Anatomical Therapeutic Chemical (ATC) and Defined Daily Dose (DDD)) / 100 patient-days methods. Based on the results of tracing medical record data, it was found that the number of pediatric patients in the Theresia room at St. Elisabeth Semarang for the period October - December 2019 is 385. The number of patients who received a single antibiotic was 162. The total value of DDD / 100 patient-days in the Theresia </em><em>ward</em><em> of St. Elisabeth</em><em> Hospital</em><em> Semarang for the period October - December 2019 is 18.17 with a total length of stay of 1117 days. The antibiotic with the highest DDD / 100 patient-days was ceftriaxone, namely 15.10. While the antibiotics that enter the DU 90% segment are ceftriaxone and cefotaxime.</em></p> Fef Rukminingsih, Apriliyani Apriliyani ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/110 Tue, 12 Jan 2021 05:57:10 +0000 PENGARUH IKLAN OBAT FLU DI TELEVISI TERHADAP PERILAKU SWAMEDIKASI http://jurnalfarmasi.or.id/index.php/jrki/article/view/103 <p><em>The high prevalence of flu and the easy availability of drugs in the market and at relatively affordable prices are one of the driving forces for self-medicating by the community. In addition, increasingly sophisticated technological advances make it easy for people to get information, one of which is drug advertisements on television that can influence consumer behavior in the selection of drugs used in self-medication. This research was conducted with the aim of knowing the effect of cold medicine advertisements on television on self-medication behavior in the community of Karang Intan District. This research method is a descriptive observational study with a cross sectional design. The sampling technique was carried out using non-random sampling method, namely accidental sampling, and the number of respondents was 100 people. The data collected comes from questionnaire data, which is filled in by respondents accompanied by researchers. Descriptive data analysis was performed by using the chi square test. The results showed that the effect of cold medicine advertisements on television on self-medicated behavior in the community of Karang Intan District has a significant p value of 0.000. The conclusion is that the advertisement of cold medicine on television has an influence on self-medication behavior in the community of Karang Intan District.</em></p> Nurul Mardiati, Robiatul Islamiyah, Rahmayanti Fitriah ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/103 Sat, 16 Jan 2021 09:23:03 +0000 FORMULASI DAN UJI DAYA HAMBAT SABUN CAIR EKSTRAK ETANOL SERAI WANGI (Cymbopogon nardus L) TERHADAP PERTUMBUHAN Staplylococcus aureus http://jurnalfarmasi.or.id/index.php/jrki/article/view/115 <p><em>Citronella (Cymbopogon Nardus.L) contains essential oil compounds, saponins, polyphenols and flavonoids which are antibacterial. The use of active compounds of Citronella is formulated into antibacterial liquid soap preparations. This study aims to determine the characteristics of liquid soap and its inhibition against the growth of Staphylococcus aureus. This research is experimental to formulate liquid soap containing ethanol extract of lemongrass sticks at concentrations of 9% (F1), 18% (F2) and 24% (F3). The test parameters for liquid soap preparations include organoleptic test (shape, aroma, color), homogeneity test, pH test, foam height test, foam stability test, free alkaline test and inhibition test against the growth of Staphylococcus aureus using the Kirby-Bauer method. The results showed that the liquid soap preparations in the F1, F2 and F3 formulas were liquid, had a distinctive aroma of Citronella and were brown in color, homogeneous. The pH values, foam height, foam stability and free alkaline content of liquid soap were F1 (12; 70 mm; 85.7% and 0.14%), F2 (11. 80 mm, 87.5% and respectively). 0.10%), F3 (10.100 mm, 90% and 0.08%). The formula inhibition zone diameters are 32.06 mm, 25.6 mm and 29.2 mm, respectively. The conclution is the characteristics of the liquid soap with the ethanol extract of Citronella (Cymbopogon Nardus.L) meet the requirements as liquid soap. The greatest inhibitory effectiveness on the growth of Staphylococcus aureus was a formula at a concentration of 24% (F3) with a strong category.&nbsp; </em></p> Rinaldi Rinaldi, Fauziah Fauziah, Rizka Mastura ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/115 Sat, 16 Jan 2021 13:52:40 +0000 IDENTIFIKASI BORAKS PADA PENTOL BAKSO YANG DI KELURAHAN AIR HITAM DENGAN PEREAKSI KULIT BUAH NAGA MERAH (Hylocereus polyhizus) http://jurnalfarmasi.or.id/index.php/jrki/article/view/125 <p><em>Borax is often misused to preserve various foods such as wet noodles, meatballs, rice cake, rhombus and so on. Red dragon fruit skin contains secondary metabolites, namely anthocyanin, anthocyanin is the most important and widespread dye in the skin of red dragon fruit, but the use of red dragon fruit peels has not been studied much naturally. The purpose of this study was to identify borax on the meatball sold in the Air Hitam district with the red dragon fruit skin reagent (Hylocereus polyhizus). This research is experimental with data collection techniques by accidental sampling. In this study used several samples of meatball pentol purchased at the meatball merchant located in Air Hitam Village by using dragon fruit peel and AgNO<sub>3</sub> reagent as a comparison indicator. This research includes plant determination, sample collection, sample preparation, spike making, dragon fruit skin extract reagents and qualitative sample testing. Data analysis using descriptive analysis method. The results of the identification of borax on 5 meatball samples using color reagents from the extract (essence) of the red dragon fruit peel and AgNO3 reagent as a comparative indicator showed that all samples of the meatball obtained Negative results</em></p> Dwi Lestari, Mutia Dewi, Suci Cahya Ningsih, Hidayati Hidayati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/125 Sun, 17 Jan 2021 19:09:47 +0000 POLA PERESEPAN ANTIBIOTIK PROFILAKSIS PRE BEDAH SECTIO CAESAREA DI RUMAH SAKIT http://jurnalfarmasi.or.id/index.php/jrki/article/view/117 <p><em>Caesarean section is a surgery to give birth to a child through surgery on the abdominal wall and uterus. Prophylactic antibiotics are preventive antibiotics in Sectio Caesarean surgery.</em><em>&nbsp;&nbsp;&nbsp;&nbsp; </em><em>This study aims to determine the pattern of prescribing prophylactic antibiotics in preoperative caesarean section patients which are grouped into 4 specific objectives, namely: patient characteristics such as (age, parity status, payment status), antibiotic class, type of antibiotic, and to determine surgical wound indication ILO</em><em>, </em><em>This study used a descriptive method by retrospectively taking data by looking at the prescription (e-prescription), patient medical record data and SOAP (Subjective, Objective, Assessment, Planning). The results showed that out of 300 patients who were parturient, 52 patients (17.3%) had normal delivery and 248 patients with caesarean delivery (82.7%). Most of the ages were between 20-30 years as many as 123 patients (49.6%) and aged &gt; 30-40 years as many as 120 patients (48.38%). As for the status of the most payments in cash, namely 176 patients (71%).</em> <em>The most frequently used antibiotic class is the Cephalosporin group, namely 246 patients (99.6%), the most commonly used type of antibiotic is Ceftriaxon, which is 175 patients (70.6%).</em> <em>The study on Surgical Wound Infection was found in only 1 patient </em><em>(0,4%) </em><em>with the antibiotic Ceftriaxon.</em></p> Chusun Saleh, Maya Kurniasari ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 http://jurnalfarmasi.or.id/index.php/jrki/article/view/117 Fri, 22 Jan 2021 18:28:41 +0000