Jurnal Riset Kefarmasian Indonesia http://jurnalfarmasi.or.id/index.php/jrki <p>"<strong>The Jurnal Riset Kefarmasian Indonesia</strong>" &nbsp;is Journal of Pharmaceutical and Health Science published by APDFI Organization (Asosiasi Pendidikan Diploma Farmasi Indonesia) covering Organization of Pharmacy, Medical, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Physical Chemistry, Biology, Microbiology, Tissue Culture, Botany and animals related to pharmaceutical products, Health Analyst, Nutrition and Public Health.</p> APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) en-US Jurnal Riset Kefarmasian Indonesia 2655-8289 UJI Brine Shrimp Lethality Test (BSLT) UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) DAN UJI TOKSISITAS AKUT FRAKSI AKTIF http://jurnalfarmasi.or.id/index.php/jrki/article/view/43 <p><em>Eleutherine bulbosa (Mill.) Urb come from the Iridaceae family, this species contains secondary metabolites in the form of flavonoids and quinones. This research method includes Brine Shrimp Lethality Test (BSLT) toxicity using Artemia salina Leach larvae to determine the LC<sub>50</sub> value. This study used experimental methods pharmacologically using a completely randomized design in the same direction pattern in the selection of test animals, 25 animals used were white mice divided into 5 groups with 5 mice per group, with 4 hours observed to find out toxic symptoms and continued observation every 24 hours to see death. Testing of BSLT results showed that ethanol extract had LC<sub>50</sub> toxicity = 66.68 ppm (very toxic category), n-hexane fraction had LC<sub>50</sub> toxicity = 47.64 ppm (very toxic category), chloroform fraction had LC<sub>50</sub> toxicity = 295.1 ppm ( toxic category), and the water fraction has a toxicity of LC<sub>50</sub> = 194.54 ppm (very toxic category). The chloroform fraction is an active fraction. Acute toxicity test LD<sub>50</sub> value according to the calculation method of Miller Tainter Probit (187,499 mg/KgBB), the method of calculation of Thompson Weil (182,810 mg/KgBB), how to calculate Indonesian Pharmacopoeia (187,068 mg/KgBB). Based on the three calculations, the LD<sub>50</sub> value is in the medium category (50-500 mg/kgBB).</em></p> Dwi Lestari Rudi Kartika Eva Marliana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-11 2019-01-11 1 1 1 10 10.33759/jrki.v1i1.43 PENETAPAN KADAR FLAVONOID EKSTRAK DAUN KELAKAI (Stenochlaena palustris (Burm. F.) Bedd.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS http://jurnalfarmasi.or.id/index.php/jrki/article/view/46 <p><em>Kelakai (Stenochlaena palustris (Burm F.) Bedd.) is a medicinal plant of Borneo. The purpose of this research is to determine the level of flavonoid in crude extract of kelakai leaf by UV-Vis Spectrophotometer. The research was conducted by collection of the kelakai leaves and plant determination. The ethanolic extract of kelakai leaves was collected using macceration methode. The determination of flavonoid level was conducted by UV-Vis Spectrophotometer using quersetin as standard compound. The study showed that the rendemen of crude extract of kelakai leaf was (22,92%). The moisture content in viscous extract was (19,71%). The level of Flavonoids in extract was (2,2159±0,083%).</em></p> Eka Siswanto Syamsul Yana Yunita Hakim Henny Nurhasnawati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-11 2019-01-11 1 1 11 20 10.33759/jrki.v1i1.46 Pemanfaatan Ekstrak Daun Teh (Camellia sinensis L) Dari Perkebunan Kemuning Kab. Karang Anyar dalam Pembuatan Sabun Padat Transparan dan Uji Aktivitas Antibakteri pada Staphyloccocus aureus http://jurnalfarmasi.or.id/index.php/jrki/article/view/7 <p><em>Kemuning’s plantations in Karang Anyar Regency are famous for their lush tea plantations and good quality. Tea leaves contain several substances including flavonoids, 30- 40% polyphenols, caffeine, essential oils and tannins. The famous tea leaf polyphenols are catechins. Catechins have properties as antidiarrheal, antibacterial, especially against Staphyloccocus aureus bacteria, which is one of the gram-positive bacteria that cause infections in the skin. Based on this, tea leaf extract can be used as a natural supplement in the manufacture of transparent soap products. In this study tea leaf extract became one of the components in making transparent soap by adding tea leaf extract to formula 1 (0%), formula 2 (1.5%), formula 3 (3%) and formula 4 (4, 5%). Then transparent soap preparations were tested for organoleptic and quality quality including moisture and vaporizing soap content, amount of fatty acids, free alkali content and levels of unbunned fractions and anti-bacterial activity against the growth of Staphyloccocus aureus bacteria. Based on the results of the study, it was found that transparent 4 solid soap with 4.5% tea leaf extract content had the darkest color of solid soap, evaporated water and substance content, free alkali content, fatty acid, acidity level (pH), unbonded fraction level and the highest foam stability. Formula 4 solid soap also has the best inhibitory power against the growth of Staphyloccocus aureus bacteria.</em></p> Iwan Setiawan Dwi Saryati Astian Astian ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-11 2019-01-11 1 1 21 29 10.33759/jrki.v1i1.7 PERBANDINGAN METODE EKSTRAKSI EKSTRAK UMBI BAWANG RAMBUT (Allium chinense G.Don.) MENGGUNAKAN PELARUT ETANOL 70% TERHADAP RENDEMEN DAN SKRINING FITOKIMIA http://jurnalfarmasi.or.id/index.php/jrki/article/view/15 <p><em>Allium chinense are plants that contain bioactive compounds such as alkaloids, flavonoids, and saponins. The rendement of an extract may be affected by the extraction mentod used. This study aims to determine the effect of maseration and digestion extraction method on rendemen and identification of secondary metabolite in the extract of the hair onion bulbs. Research conducted is an experimental study. &nbsp;The samples used were hair bulbs obtained in Kota Bangun, East Kalimantan, extracted wiyh 2 extraction methods of maceration and digestion using ethanol 70% solvent and done as much as 3 times replication. Identification of secondary metabolite compounds was performed by phytochemical screening including test of alkaloids, flavonoids, saponins, tannins, and steroids. From the test data is processed by statistical analysis. The result of rendement with 3 times replikation of digesti mentod obtained by 20,02 gram, 19,03 gram, and 19,17 gram. While the maseration method obtained for 12,38 grams, 12,45 grams, and 15,91 grams. So there are differences between the results of the results of digestion mentod and maseration mentod. Based on phytochemical screening tets showed that the thick extract of hair onion bulbs contain compounds alkaloids, flavonoids, and saponins.</em></p> Supomo Supomo Husnul Warnida Bagus Moch Said ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-11 2019-01-11 1 1 30 40 10.33759/jrki.v1i1.15 KAJIAN PENGOBATAN TRADISIONAL CACAR MENURUT TERJEMAHAN LONTAR USADA KACACAR http://jurnalfarmasi.or.id/index.php/jrki/article/view/12 <p><em>The Traditional medicine in Bali is a concept of Balinese culture that is used for generations. Usada is a knowledge of traditional Balinese medicine as a source of concepts to solve problems in the health sector. Healing (usada) is found in lontar called lontar usada. Lontar Usada Kacacar is one of the usada which discusses smallpox. The purpose of this study is to find out information contained in Lontar Usada Kacacar. Information includes the type of smallpox, treatment ingredients, dosage form and method of use. In addition, in research can be inform a plants that are used as traditional smallpox drugs. Healing in Bali is based on lontar, the research this time was carried out on eaves of Usada Kacacar. This research was conducted descriptively to the translation of Lontar Usada Kacacar translated by I Gusti Ngurah Wiriawan, S.S. The results of the translation of Lontar Usada Kacacar made in table form include the types of smallpox, medicinal herbs, how to use and use spells. The results of the table found information on 100 medicinal herbs, 75 types of smallpox, 107 types of plants, 10 types of methods of use and 16 methods of treatment accompanied by spells.</em></p> I Nyoman Gede Tri Sutrisna Ni Luh Gede Widyastuti Kadek Duwi Cahyadi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-15 2019-01-15 1 1 41 55 10.33759/jrki.v1i1.12 EVALUASI SIFAT FISIK SEDIAAN SHAMPO EKSTRAK DAUN KATUK (Sauropus androgynus (L) Merr) DENGAN BERBAGAI VARIASI VISCOSITY AGENT http://jurnalfarmasi.or.id/index.php/jrki/article/view/6 <p><em>Sauropus androgynus </em><em>(L) Merr leaf in Indonesia called katuk have strong antioxidant activity with IC50 80,01 ppm. The aims of this research is want to know physical properties of katuk leaf shampo which is formulated in various formulas. In this research katuk was formulated in shampoo with viscocity agent (HPMC, sodium CMC and Carbopol) in various concentration. The result showed that all shampoo formulas had low jasmine smell, but had different in form and colour. Shampoo viscocity increased with increased viscocity agent. The highest viscocity showed by F7 with 0,5% carbopol concentration. pH test showed that the shampoo with HPMC and sodium CMC had pH value 6. pH value of shampoo with carbopol was 5. All of pH formulas meet the requirement of SNI standard. Statistical result showed that the physical properties of foam high, viscocity and pH all formulas had significant difference.</em></p> <p><strong><em>&nbsp;</em></strong></p> Dewi Rashati Mikhania Christiningtyas Eryani ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-19 2019-01-19 1 1 56 63 10.33759/jrki.v1i1.6 POLA PENGGUNAAN OBAT ANTIRETROVIRAL (ARV) PADA RESEP PASIEN RAWAT JALAN DARI KLINIK HIV/AIDS SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG http://jurnalfarmasi.or.id/index.php/jrki/article/view/10 <p><strong><em>ABSTRACT</em></strong></p> <p><em>The Human Immunodeficiency Virus (HIV) continues to be a major global public health issue, which targets the human immune system. The using of ARVs in the treatment of HIV / AIDS increased life expectancy for PLHIV (People With HIV / AIDS). This study aims to determine the description of the using of ARV drugs in outpatients of the HIV / AIDS Clinic and assessed their suitability with established treatment standards. This research was carried out in a descriptive non-experimental manner, with data collection carried out retrospectively, used patient prescription data from April to December 2017. The results of quantitative studies showed 87% were male patients, and the largest age group was 20-29 years (39%) . Class of antiretroviral drugs used were Nucleoside / Nucleotide Reverse Transcriptase Inhibitors (NRTIs), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), and Protease Inhibitors (PI), with a combination of antiretroviral drugs most was the combination of first-line tenofovir + lamivudine + efavirenz (69%) while the second-line drug zidovudine + lamivudine + lopinavir / ritonavir&nbsp; was 1%. The most commonly used comorbid drug was cotrimoxazole. For qualitative data, the accuracy of combination and dose of ARV drugs was 100% in accordance with </em>Permenkes No. 87/ 2014<em>, with 79% of patients adhered to antiretroviral treatment every month. The potential for most ARV drug interactions with other drugs for the moderate category was zidovudin + cotrimoxazole (11%) which occured pharmacokinetically by decreasing renal clearance of zidovudine and glucuronide metabolites. In conclusion, the pattern of used of ARV drugs had met the standard of </em>Permenkes No.87/2014<em>, with the most used were the first line combination of tenofovir + lamivudine + efavirenz.</em></p> Ani Anggriani Ida Lisni Olga Susana Liku ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-19 2019-01-19 1 1 64 81 10.33759/jrki.v1i1.10 PENGARUH EDUKASI FARMASIS TERHADAP MOTIVASI DAN KEPATUHAN PENGGUNA PROGRAM TERAPI RUMATAN METADON DI PUSKESMAS TAMBORA PADA BULAN FEBRUARI - APRIL 2015 http://jurnalfarmasi.or.id/index.php/jrki/article/view/8 <p style="margin-left: 18.95pt; text-align: justify;"><em>This study was triggered by the large number of users of Methadone Maintenance Therapy Program (MMTP) who Dropped Out due to lack of motivation and compliance. The purpose of this study was to increase the motivation and compliance of the Tambora Community Health Center MMTP users. The study design used the quasi-experimental method with the pretest-the posttest the group was not comparable. Voluntary research samples amounted to 100 with a distribution of @ 50 for the control group (KK) and @ 50 for the treatment group (KE). Based on the results of data analysis, the following results were obtained: (1) There was an increase in the motivation and compliance variables for the group given education with lectures and leaflets. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously can increased the motivation of users with a score of 15.4% (p value 0.00 &lt;0.05) in MMTP at the Tambora Community Health Center. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously increases the compliance of service users in MMTP Tambora Community Health Center with a score of 12.7% (p value 0.00 &lt;0.05). The Conclusion pharmacist education can increase motivation and compliance to users of Tambora Community Health Center MMTP services.</em></p> Marta Halim Shirly Kumala Yetti Hersunaryati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2019-01-20 2019-01-20 1 1 82 92 10.33759/jrki.v1i1.8