Jurnal Riset Kefarmasian Indonesia http://jurnalfarmasi.or.id/index.php/jrki <p><strong>Jurnal Riset Kefarmasian Indonesi (JRKI)</strong> adalah Jurnal dengan akses terbuka (Open Access) yang memuat artikel tentang ruang lingkup kefarmasian seperti&nbsp;Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang berkaitan dengan produk farmasi, Analis Kesehatan, Gizi serta Kesehatan Masyarakat.</p> <p>Jurnal ini diterbitkan 3x dalam satu tahun yaitu dibulan <strong>Januari, Mei dan September. </strong>Jurnal Riset Kefarmasian Indonesia (JRKI)<strong>&nbsp;</strong>ditetapkan sebagai Jurnal Ilmiah&nbsp;Terakreditasi Peringkat 5&nbsp;(Sinta 5) berdasarkan Keputusan Menteri Riset dan Teknologi/Kepala Badan Riset dan Inovasi Nasional Nomor: 158/E/2021 dengan masa berlaku mulai <strong>Volume 1 Nomor 3, Th 2019</strong> hingga <strong>Volume 6 Nomor 2, Th 2023</strong></p> <p><strong>Jurnal Riset Kefarmasian Indonesia (JRKI)&nbsp;&nbsp;</strong>telah terindeks di Google Scholar, PKP Index, One Search Indonesia (IOS), Garuda Dikti, Crosreff, Dimension, Neliti dan SINTA Kemendikbud Dikti.</p> APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) en-US Jurnal Riset Kefarmasian Indonesia 2655-8289 GAMBARAN FUNGSI HATI PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK PERIODE OKTOBER-DESEMBER 2020 http://jurnalfarmasi.or.id/index.php/jrki/article/view/262 <p><em>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </em><em>Type II DM patients use Oral Antidiabetic Agent (OAA) continuously for a long time. OAA metabolism occurs in the liver. The use of OAA continuously in the long term can cause liver function disorders. The purpose of this study was to describe the liver function of type II DM patients who were treated with OAA in a private hospital in Demak District. This study is an observational descriptive study using retrospective data obtained from medical record documents of outpatients with type II DM for the period October – December 2020.</em> <em>Sampling using purposive sampling technique</em>.<em> The inclusion criteria were outpatients with type II DM, JKN participants who received OAA therapy for at least one year, aged 36 – 65 years old, have AST and ALT laboratory examinations. Patients who received combination therapy with insulin, had a history of impaired liver function were excluded. The results showed that from 62 patients there were 39 female patients (62.9%), the most patients aged 56-65 years were 32 patients (51.61%). The longest duration of use of OAA was 1 year, namely 29 patients (46.77%). The most widely used OAA was a combination of biguanides and sulfonylureas in 36 patients (58.07%). A total of 51 patients (82.25%) did not experience liver function damage and as many as 11 patients (17.75%) showed mild liver function damage with the duration of using OHO for more than 1 year and using OHO combination.</em></p> Megi Pangestuningsih Fef Rukminingsih ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 134 143 10.33759/jrki.v4i2.262 UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BATANG SEKILANG (Embelia borneensis Scheff) TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus MENGGUNAKAN METODE DISC DIFFUSION http://jurnalfarmasi.or.id/index.php/jrki/article/view/260 <p><em>Sekilang is one of the plants in North Kalimantan and is found in the Ampan Ibau Forest. This plant is empirically used by the people of Long Temuyat Village as a poison from natural ingredients to catch fish and as a leech repellent. The content of active compounds in sekilang bark extract include alkaloids, tannins, saponins, flavonoids. These compounds have the potential as antibacterial, so it is necessary to test the antibacterial activity. The purpose of this study was to determine the antibacterial activity of the sekilang bark extract against Escherichia coli and Staphylococcus aureus bacteria. The research phase included plant determination, sample collection, maceration extraction, and antibacterial activity test using the disc diffusion method with extract concentrations of 20%, 30%, and 40%.&nbsp;</em><em>The results showed that the ethanol extract of the bark of sekilang has the potential to inhibit bacterial growth. The antibacterial activity of the bark extract of the cruciferous plant against Escherichia coli bacteria at concentrations of 20%, 30% and 40%, respectively, was 5.9 mm, 6.7 mm and 5.9 mm. Meanwhile, the activity of the bark extract against Staphylococcus aureus at concentrations of 20%, 30% and 40%, respectively, was 7.6 mm, 6.8 mm and 8.0 mm. The antibacterial activity of the bark extract against both bacteria was included in the moderate criteria. </em></p> Inayah Herman Goetie Reksi Sundu Risa Supriningrum ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 144 155 10.33759/jrki.v4i2.260 PENGARUH PERBEDAAN METODE EKSTRAKSI DAUN JATI (Tectona grandis L.f) TERHADAP AKTIVITAS ANTIBAKTERI PADA Escherichia coli http://jurnalfarmasi.or.id/index.php/jrki/article/view/259 <p><em>The use of teak is limited to wood and stems with high economic value. The part of the teak that has not been utilized optimally is the teak leaf. Teak leaves are only used traditionally as food wrappers and traditional medicines. According to several studies, Sumthong (2007) in Setyawan (2012) stated that teak leaves contain several bioactive compounds, namely tektoquinone, tannic acid, gallic acid and several other organic acids. The presence of bioactive compounds in teak leaves can also be used as an antibacterial agent. This study was conducted to determine the effect of different extraction methods maceration, percolation and microwave Microwave Assisted Extraction on the antibacterial activity of teak leaves against Escherichia coli bacteria. From the research, it can be concluded that the different extraction methods of teak (Tectona grandis L.f) leaves have a significant effect on the antibacterial activity of Escherichia coli and the microwave extraction method is effective as an antibacterial against Escherichia coli as seen from the clear zone produced which is greater than the maceration and percolation extraction methods.</em></p> Dwi Kurniawati Sambodo Fransiska Marsel Herlina Prasetyowati Sambodo Nandia Arlesia ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 156 173 10.33759/jrki.v4i2.259 Daya Hambat Hand Sanitizer di Masyarakat: Apakah Efektif ? http://jurnalfarmasi.or.id/index.php/jrki/article/view/250 <p><em>Hand sanitizer is one of the Household Health Supplies (PKRT) which is one of the human needs when the Covid-19 pandemic appears throughout the world. Panic at the beginning of the spread of Covid-19 has caused many people to buy and store hand sanitizers, resulting in shortages everywhere. WHO announced the composition for the manufacture of hand sanitizers. And the government allows making hand sanitizers without going through actual regulations so that hand sanitizers appear in several dosage forms such as sprays and gels suitable for antiseptic purposes. The inhibition of hand sanitizers against microbes needs to be tested considering its function as a microbial exterminator on human hands, so this research needs to be done to determine the effectiveness of hand sanitizers circulating in the community. The microbes used are Staphylococcus aureus and Escherichia coli. The sampling technique was carried out by purposive sampling and its effectiveness by using the disc diffusion method. The results obtained are that all hand sanitizers sampled have a diameter of inhibition as a strong antiseptic 10%, 50% sufficient and 40% weak.</em></p> Tuty Taslim Reny Salim Irene Puspa Dewi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 174 184 10.33759/jrki.v4i2.250 PENETAPAN KADAR AIR SIMPLISIA DAUN KEMANGI (Ocimum basilicum L.) BERDASARKAN PERBEDAAN METODE PENGERINGAN http://jurnalfarmasi.or.id/index.php/jrki/article/view/246 <p><em>Drying is one of the steps in making basil leaves simplicia. Drying is done to reduce the water content of simplicia. This study aims to determine the effect of the drying method on the water content of simplicia basil leaves.</em> <em>This research is an experimental post</em><em>-</em><em>test only group design. The basil leaves were dried using 2 methods, namely the direct sunlight method with a black cloth cover and the oven method at 50</em><em>°</em><em>C for 7 hours. The dried simplicia was then determined the water content using the gravimetric method. The water content data were analyzed using the Shapiro-Wilk test to determine the normality of the data, followed by the Independent T</em><em>-</em><em>test with a 95% confidence level.</em> <em>The results showed that the average moisture content of the drying method using the oven was 9,58±0.15% and the drying method using sunlight was 11,39±0.15%. These results indicate a significant difference</em><em> (p≤0,05)</em><em>. Th</em><em>is study concludes </em><em>that different drying methods can affect the water content of basil leaves simplicia</em></p> Andi Wijaya Noviana Noviana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 185 194 10.33759/jrki.v4i2.246 OPTIMASI FORMULA BODY BUTTER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn) DENGAN BASIS COCOA BUTTER DAN MILK BUTTER http://jurnalfarmasi.or.id/index.php/jrki/article/view/242 <p><em>Guava leaf extract is known to contain flavonoids, a class of flavone compounds that have very strong antioxidant activity. The antioxidant activity of guava leaf ethanol extract as measured by the DPPH method showed an IC<sub>50</sub> value of 72 µg/ml.</em> <em>Body butter preparations have a better ability to nourish and maintain skin moisture because they contain high oil components. Cocoa butter and milk butter are the bases that are widely used in body butter formulas and are able to maintain skin health. This study aims to determine the area of </em><em>o</em><em>ptimum composition of the combination of cocoa butter and milk butter in body butter preparations of guava leaf ethanol extract (Psidium guajava L.). This study used a factorial design with two factors, namely cocoa butter and milk butter and two levels, namely 2% and 4% for cocoa butter and 2% and 15% for milk butter. The observed responses were pH and </em><em>spreadibility</em><em> with data analysis using Design Expert and SPSS software. Based on the results of the research, the optimum area for the combination of cocoa butter and milk butter with the pH equation is Y = 6.00000 – 1.77504(X1) – 4.73345 (X2) + 1.8336(X1X2) and the dispersion equation is Y = 3 ,77692+0,366667(X1) – 0,005128(X2) + 0.033333(X1X2</em><em>)</em><em>. The optimal composition area of cocoa butter and milk butter has been validated on the combination of 3% cocoa butter and 8</em><em>,</em><em>5% milk butter</em><em>.</em></p> I Gede Made Suradnyana I Komang Gede Mahardika Nyoman Budiartha Siada ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 195 214 10.33759/jrki.v4i2.242 EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI RUMAH SAKIT BHAYANGKARA KUPANG PERIODE JULI – DESEMBER 2019 http://jurnalfarmasi.or.id/index.php/jrki/article/view/243 <p><em>Pneumonia is a disease in Indonesia that has a high mortality rate in 2018. Pneumonia is an inflammation of the lungs caused by microorganisms (bacteria, viruses, fungi, parasites). Pneumonia caused by Mycobacterium tuberculosis is not included. While lung inflammation caused by non-microorganisms (chemicals, radiation, aspiration of toxic substances, drugs, etc.) is called pneumonitis. One of the treatment for pneumonia is antibiotics where the incidence of resistance in patients often occurs due to irrational use, therefore it needs to be monitored and evaluated by health workers. The purpose of this study was to determine the use of antibiotics in pneumonia patients at Bhayangkara Hospital Kupang with the Gyssens method according to the Minister of Health of the Republic of Indonesia No. 8 of 2015. The Gyssens method is an evaluation of the use of antibiotics to assess the accuracy of the use of antibiotics which includes the accuracy of indications, the accuracy of selection based on effectiveness, toxicity, price and spectrum, duration of administration, dose, interval, route and time of administration. The method used is non-experimental with a descriptive research design, the sample taken is 25 medical record data. The results of the research category 0 (precise and rational) were 84% or in other words the use of antibiotics was rational, category IVb (there were antibiotics that were less toxic) was 12% and in category IIb (inappropriate interval antibiotics) was 4%.</em></p> Muhammad Yusuf Nielma Auliah Hana Evangelista Sarambu ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 215 229 10.33759/jrki.v4i2.243 ANALISIS EFEKTIVITAS BIAYA METODE KB DAN KUALITAS HIDUP AKSEPTOR DI PUSKESMAS LOA JANAN http://jurnalfarmasi.or.id/index.php/jrki/article/view/237 <p><em>Family Planning (KB) is a national scale program to reduce birth rates and control population growth in Indonesia. Family planning has three phases. The first phase is the phase of delaying/preventing pregnancy. The second is the phase of spacing out pregnancies, and the third is the phase of terminating/terminating pregnancy/fertility. The use of contraceptives in family planning is an effort to prevent pregnancy. The most common contraceptive methods are the pill, injection, and IUD. The purpose of this study was to determine the cost-effectiveness of the use of oral contraceptive pills, contraceptive injections, and IUD at the Loa Janan Health Center. This study used a sample of 42 acceptors. The average cost of injection contraceptives is (Rp 25,000), pills (Rp 15,000), IUD (Rp 107,000) and the effectiveness of injection contraceptives (0.95%), pills (0.857%), and IUDs (0.867%). The ACER (Average cost-effectiveness ratio) value of injection contraceptives was Rp. 26,315, and 75% of the acceptors had an average quality of life. The ACER value of the pill was Rp. 17,502, and 85.7% of the acceptors had a good quality of life, the ACER value of the IUD was Rp. 123,414, and 60% of the acceptors had a good quality of life. The Pill-Injection's ICER (incremental cost-effectiveness ratio) value is Rp. 107,526. The ICER of IUD-Injection is Rp. -987,951, and the IUD-Pill (Rp.9,200,000). Hence, oral contraceptive gave a good quality of life and is more cost-effective than contraceptive injection and IUDs.</em></p> <p><strong><em>Keywords:</em></strong> <em>Cost-Effectiveness Analysis, IUD, injection contraceptive, oral contraceptive, </em><em>Loa Janan Health Center</em></p> Wiwid Verri Yanti Husnul Warnida Triswanto Sentat ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 230 246 10.33759/jrki.v4i2.237 EVALUASI MUTU FISIKA DAN KIMIA SEDIAAN KRIM LIP AND CHEEK DENGAN PEWARNA ALAMI EKSTRAK BUAH NAGA SUPER MERAH (Hylocereus Costaricensis) http://jurnalfarmasi.or.id/index.php/jrki/article/view/272 <p><em>Lip and cheek</em>&nbsp;adalah kosmetik dwifungsi yang dapat digunakan sebagai pewarna bibir sekaligus perona pipi. Berdasarkan hasil pengawasan BPOM diketahui banyak pewarna sintetis berbahaya yang disalahgunakan sebagai pewarna kosmetik. Buah naga super merah diketahui dapat digunakan sebagai pewarna alami karena memiliki kandungan zat warna antosianin. Antosianin adalah zat warna yang berperan memberikan warna merah berpotensi menjadi pewarna alami untuk pangan ataupun untuk kosmetik, sebagai pengganti pewarna sintetis yang lebih aman bagi kesehatan. Oleh karena itu, pada penelitian ini dilakukan evaluasi mutu fisik sediaan <em>lip and cheek</em> dengan pewarna alami ekstrak buah naga super merah. Sediaan dibuat menggunakan dua variasi formula, yaitu F0 dengan konsentrasi ekstrak 0% sebagai kontrol dan F30 dengan konsentrasi ekstrak 30%. Ekstrak buah naga super merah dibuat menggunakan metode maserasi daging buah naga selama tiga hari dengan pelarut etanol 96% yang kemudian dipekatkan dengan <em>rotary evaporator</em> hingga menjadi ekstrak kental. Daging buah naga dipilih karena kadar antosianin yang terkandung lebih tinggi dibandingkan antosianin yang terdapat pada kulit buah naga. Sediaan dibuat dengan mencampur Fasa I yang sudah mencair dengan Fasa II menggunakkan <em>homogenizer</em>. Krim Lip &amp; Cheek secara organoleptik merupakan sediaan semi padat dengan warna merah muda, memiliki bau khas, dan homogen. Serta memiliki pH 5,01 dengan nilai viskositas 209.200 cps.</p> Mega Efrilia Ika Agustina Tri Lestari ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 247 255 10.33759/jrki.v4i2.272 GAMBARAN PENGETAHUAN MASYARAKAT TENTANG SWAMEDIKASI SAKIT GIGI DI RW 044 KELURAHAN BAHAGIA, BEKASI UTARA http://jurnalfarmasi.or.id/index.php/jrki/article/view/270 <p><em>The practice of self-medication is a lot of medication errors. Medication errors due to a lack of drug information. Self-medication is defined as the selection and use of medicines both herbal and synthetic drugs by a person to treat a disease or symptom that is self-recognized. In self-medication, it is best to follow the rational drug use requirements. The use of a drug is said to be irrational if the possibility of negative impacts received by the patient is greater than the benefits. The purpose of this study was to find out the description of knowledge about dental pain self-medication in RW 044 Bahagia, North Bekasi in April 2020, regarding the understanding of dental pain self-medication, the use of chemical drugs in dental pain self-medication, the use of traditional medicines in self-medication dental pain, where to get medicine for self-medication of dental pain, the reasons for self-medication of dental pain, and a source of drug information in self-medication for dental pain. The research method used is a descriptive research method to the community at RW 044 with the provision that 1 KK completes 1 questionnaire, with an age range of 25-64 years. The results of this study have a sufficient level of knowledge of 70 respondents (53.03%), So it can be concluded that the picture of community knowledge in RW 044 Bahagia, North Bekasi is sufficient. </em></p> Honey Iskandar Yudha Sukowati Aries Meryta Noor Affni Setyaningrum ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 256 269 10.33759/jrki.v4i2.270 GAMBARAN PENGGUNAAN OBAT PADA PASIEN PENYAKIT GINJAL KRONIK (PGK) YANG MENJALANI HEMODIALISIS DI RS X BEKASI PERIODE JANUARI – MARET 2020 http://jurnalfarmasi.or.id/index.php/jrki/article/view/269 <p><em>Chronic Kidney Disease (CKD) is a condition of kidney damage that occurs for 3 months or more in the form of structural or functional abnormalities of the kidneys with or without a decrease in the Glomerular Filtration Rate. So far, treatment for CKD can be done by hemodialysis, Continuous Ambulatory Peritoneal Dialysis (CAPD) and kidney transplantation. This study aims to determine the description of the use of drugs in CKD patients undergoing hemodialysis at Hospital X Bekasi from January to March 2020. This study was conducted using a descriptive method. Sampling in January - March 2020 was carried out with the total sampling method, namely all electronic prescription sheets of CKD patients undergoing hemodialysis at Hospital X Bekasi. Data were collected by calculating the amount and percentage based on the active substance and class of drugs used by CKD patients undergoing hemodialysis. Based on the results of observations of electronic prescriptions of drugs used by CKD patients undergoing hemodialysis at Hospital X Bekasi during January - March 2020, it can be concluded that the use of drugs based on the active substance is Calcium carbonate 500 mg capsules as many as 10580 capsules (59.07%), Sodium bicarbonate 500 mg tablets 1725 tablets (9.63%), Gentamicin sulfate 80 mg/2 ml inj 868 ampoules (4.85%), Vitamin C (ascorbic acid) 200 mg/2 ml inj 753 ampoules (4.21% ), Recombinant human erythropoietin 3000 IU 678 injection (3.78%).</em></p> Niko Prasetya Herty Nur Tanty Honey Iskandar Retnayu Pranacistri ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 270 278 10.33759/jrki.v4i2.269 GAMBARAN TINGKAT PERSEDIAAN OBAT ANTI HIPERTENSI DI APOTEK IMPHI PERIODE JANUARI – MARET 2020 http://jurnalfarmasi.or.id/index.php/jrki/article/view/271 <p><em>Hypertension or high blood pressure is the condition when blood pressure is at the value of 130/80 mmHg or more. This condition can be dangerous, if the patient's treatment is constrained by the quality management of a poor pharmaceutical installation (pharmacy). Efficient drug management is one of the most important factors in the success of overall management so that patients can obtain maximum treatment, and aim to avoid excess (stagnant) and deficiency (stockout) drug availability in pharmacies. The study aims to determine the degree of antihypertensive drug supply at Imphi Pharmacy from January to March 2020. This type of research uses non-experimental methods, which are types of research using quantitative descriptive methods. The sampling method uses a total sampling. The result is that all groups of antihypertensive drugs meet the average supply level of three months with a supply rate of ≥ 1.00 months, and there are two categories of drug stocks are ideal stock (supply levels ≥ 1.00 to ≤ 3.00) and stock is not ideal (inventory levels ≥ 3.00) and the most widely used antihypertensive drugs amlodipine 5 mg with an average use of 3 months as many as 1880 tablets with a stock rate of 1.22 months. All classes of antihypertensive drugs at Imphi Pharmacy each have a slowmoving drug resulting in a high level of drug supply. High levels of drug supply are influenced by several factors such as the number of declining drug requests, excess stock in the warehouse, and the transfer of the drug from generic to patent or otherwise by a physician.</em></p> Aries Meryta Guruh Subagya Niko Prasetya M Arman Maulana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05-31 2022-05-31 4 2 279 288 10.33759/jrki.v4i2.271