Jurnal Riset Kefarmasian Indonesia http://jurnalfarmasi.or.id/index.php/jrki <p><strong>Jurnal Riset Kefarmasian Indonesi (JRKI)</strong> adalah Jurnal dengan akses terbuka (Open Access) yang memuat artikel tentang ruang lingkup kefarmasian seperti&nbsp;Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang berkaitan dengan produk farmasi, Analis Kesehatan, Gizi serta Kesehatan Masyarakat.</p> <p>Jurnal ini diterbitkan 3x dalam satu tahun yaitu dibulan <strong>Januari, Mei dan September. </strong>Jurnal Riset Kefarmasian Indonesia (JRKI)<strong>&nbsp;</strong>ditetapkan sebagai Jurnal Ilmiah&nbsp;Terakreditasi Peringkat 5&nbsp;(Sinta 5) berdasarkan Keputusan Menteri Riset dan Teknologi/Kepala Badan Riset dan Inovasi Nasional Nomor: 158/E/2021 dengan masa berlaku mulai <strong>Volume 1 Nomor 3, Th 2019</strong> hingga <strong>Volume 6 Nomor 2, Th 2023</strong></p> <p><strong>Jurnal Riset Kefarmasian Indonesia (JRKI)&nbsp;&nbsp;</strong>telah terindeks di Google Scholar, PKP Index, One Search Indonesia (IOS), Garuda Dikti, Crosreff, Dimension, Neliti dan SINTA Kemendikbud Dikti.</p> APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) en-US Jurnal Riset Kefarmasian Indonesia 2655-8289 OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN http://jurnalfarmasi.or.id/index.php/jrki/article/view/224 <p><em>Transdermal patch is drug delivery system that is pasted through the skin. These preparations can provide a constant drug release, easy to use, reduce the frequency of drug administration, eliminate first-pass metabolism, and reduce side effects such as gastric irritation and improve patient compliance. Blue pea (Clitoria ternatea L.) contains flavonoid compounds that have anti-inflammatory activity. This study aims to obtain the optimal comparison of HPMC and Na CMC as a polymer in the transdermal patch formula of the ethanol extract of the blue pea (Clitoria ternatea L.). Optimization was carried out using the Simplex Lattice Design method with Software Design Expert version 11. The responses used included pH tests, weight tests, thickness tests, folding tests and moisture content tests. The optimal formula obtained from the Simplex Lattice Design method was verified with the SPSS program using the one sample t-test method. The optimal formula of transdermal patch of blue pea ethanol extract was tested for acceptability to determine whether it was acceptable to the respondent or not. The optimal comparison of HPMC and Na CMC as a polymer with transdermal patch preparation of blue pea ethanol extract was 3.5%:1%, with a desirability value of 0.944. </em></p> Dwi Saryanti Ita Mustika Putri Setyadi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-29 2022-09-29 4 3 289 305 10.33759/jrki.v4i3.224 EVALUASI FORMULASI MASKER CLAY DARI EKSTRAK ETANOl DAUN PEPAYA (CARICA PAPAYA L.) SEBAGAI ANTI JERAWAT http://jurnalfarmasi.or.id/index.php/jrki/article/view/283 <p><em>Papaya Leaf Extract is known to contain alkaloid and flavonoid compounds that can inhibit the preparation of peptidoglycan in bacterial cells and reduce immunity in target organisms. For ease of use of papaya leaf extract, it is formulated in the form of a mask. This study aims to formulate a clay mask from papaya leaf ethanol extract and the effectiveness of anti-acne use of clay mask preparation of papaya leaf ethanol extract for 4 weeks. The method used in this study is an experimental method carried out at the AKAFARMA laboratory in Banda Aceh. The samples used were Formula 0, Formula 1, Formula 2 and Formula 3 masks of papaya leaf ethanol extract with concentrations for Formula 1 (2.5 %), Formula 2 (5%) and Formula 3 (7%). The results of the research on the physical properties and stability of the clay mask preparation on organoleptic testing showed that all formulas did not change color and odor for 4 weeks, but there was a change in shape at F0, FI, and FII on the 28th day. The homogeneity test of all preparations showed a homogeneous arrangement. The resulting pH test is 5.7-6.5, the resulting dispersion test is 5-5.5. The dried preparation test resulted in 25-30 minutes. and the anti-acne effectiveness test of each mask preparation F0, FI, FII, and FIII the average percentage reduction in the number of acne was 20.83%, 22.63%, 28.75%, and 50%. Papaya leaf ethanol extract clay mask FIII (7.5%) was the maximum in reducing the number of pimples on the volunteers' faces. The conclusion in this study is that papaya leaves can be formulated as a clay mask.</em></p> Fauziah Fauziah Nurliza Alvanny Kiki Andalia ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-29 2022-09-29 4 3 306 320 10.33759/jrki.v4i3.283 FORMULASI DAN EVALUASI FISIK MASKER GEL PEEL OFF DARI SERBUK SISIK IKAN MUJAIR (Oreochromis mossambicus) http://jurnalfarmasi.or.id/index.php/jrki/article/view/290 <p>Masker gel <em>peel off </em>merupakan salah satu kosmetik yang digunakan untuk perawatan kulit yang dapat memutihkan, mengecilkan pori-pori, melembabkan dan menutrisi kulit. Salah satu bahan yang dapat dijadikan bahan utama masker gel <em>peel off </em>adalah sisik ikan mujair (<em>Oreochromis mossambicus)</em>. Sisik ikan mujair mengandung kolagen yang bermanfaat sebagai <em>antiaging</em>. Penelitian ini bertujuan untuk mendapatkan formula masker gel <em>peel off</em> dari sisik ikan yang terbaik dengan memvariasikan konsentrasi PVA (5% dan 10%) dan HPMC (2% dan 4%). Dalam penelitian ini dibuat 4 formula yang berbeda. Pada sediaan dilakukan pengujian karakteristik yang meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji waktu mengering, dan uji hedonik. Hasil penelitian menunjukkan sediaan yang dibuat sudah memenuhi kriteria. Semua formula memiliki tekstur semi padat, beraroma jeruk, dan berwarna abu-abu dan semua formula menunjukkan homogenitas yang baik. Hasil uji pH diperoleh: F1 (5,0), F2 (5,6), F3 (5,5), dan F4 (5,4). Hasil uji daya lekat diperoleh: F1 (400 g : 5,2 cm), F2 (600 g : 5,2 cm), F3 (600 g : 5,4 cm), dan F4 (600 g : 5,4 cm). hasil uji waktu mengering: F1 (55 menit), F2 (33 menit), F3 (33,3 menit), F4 (56,3 menit). Dapat disimpulkan bahwa serbuk sisik ikan mujair dapat dijadikan sediaan masker gel <em>peel off. </em>Formula 2 menjadi formula terbaik dengan konsentrasi PVA 10% dan HPMC 2%.</p> Mutmainnah Mutmainnah Abulkhair Abdullah Muvida Syawie ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 321 331 10.33759/jrki.v4i3.290 FORMULASI LULUR BODY SCRUB BERAS KETAN HITAM (ORYZA SATIVA VAR. GLUTINOSA) DENGAN PERPADUAN YOGURT SEBAGAI ZAT AKTIF http://jurnalfarmasi.or.id/index.php/jrki/article/view/293 <p><em>Scrub is a cosmetic preparation for skin care that functions as an abrasive in the form of scurb granules that can remove dead skin cells from the epidermis. The scrub used in this study was derived from black glutinous rice (Oryza Sativa Var. Glutinosa) which contains antioxidant components and can help activate vitamin B1 which helps maintain healthy skin and helps skin look brighter. In addition, the components of the active substance are also needed. Yogurt was chosen as the active ingredient of the preparation because it has Alpha Hydroxy Acid (AHA) which can help the exfoliation process and help remove dead skin cells and increase the skin's natural moisture factor. The purpose of making body scrub preparations using yogurt as an active substance with varying concentrations of 0%, 5%, 10% and 15%. This research was conducted experimentally. The physical quality test of the preparation includes organoleptic test, homogeneity test, pH test, adhesion test, dispersibility test, stability test, and emulsion type test. The results show that the preparations made meet the physical evaluation of the scrub preparations meet the quality requirements, meet the organoleptic quality evaluation, namely the formulation of the scrub preparations F0, F1, F2, and F3 with semi-solid texture, purplish gray color with a mixture of black glutinous rice and yogurt. Each preparation is homogeneous. Emulsion type o/w. pH ranged from 7, 45 - 6, 74. It complies with the quality requirements of the spreadability test and has good emulsion stability. The conclusion of this study is that the F3 formulation with the addition of 15% yogurt has the best physical quality in the organoleptic test, homogeneity test, pH test, dispersibility test, stability test, and emulsion type test.</em></p> Shelly Dwi Agata Lukky Jayadi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 332 352 10.33759/jrki.v4i3.293 PENETAPAN KADAR ALKALOID TOTAL PADA EKSTRAK N-HEKSAN DAN ETANOL BIJI KETUMBAR (Coriandrum sativum) MENGGUNAKAN SPEKTROFOTOMETER UV-Vis http://jurnalfarmasi.or.id/index.php/jrki/article/view/268 <p><em>Coriander (Coriandrum sativum) is one of the medicinal plants which is known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects as antimalarials and cancer. Research in determining the alkaloids in coriander was carried out by separating the alkaloids from other substances using the soxhlet method extraction with two solvents ethanol and n-hexane. The total alkaloid content is determined using a UV-VIS spectrophotometer at wavelength 351,5 nm. The reaction of alkaloids with Bromocresol green (BCG) is obtained to form a yellow product. The use of berberine standard was obtained the total alkaloid content of ethanol and n-hexane extract in coriander seed (Coriandrum sativum) were 0.524% and 0.583% respectively, and the ratio of total alkaloid content of ethanol extract was smaller than that of n-hexane extract.</em></p> lindawati setyaningrum Dhina Ayu Susanti ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 353 365 10.33759/jrki.v4i3.268 PENGARUH KOMBINASI SODIUM LAURIL SULFAT DAN NATRIUM KLORIDA TERHADAP KARAKTERISTIK SAMPO EKSTRAK LIDAH BUAYA http://jurnalfarmasi.or.id/index.php/jrki/article/view/304 <p><em>The shampoo industry in Indonesia is growing. The shampoo formulation contains 2 main ingredients, namely sodium lauryl sulfate (SLS) and sodium chloride (NaCl). One example of natural ingredients in the manufacture of shampoo is Aloe Vera (Aloe vera L.). This study aims to determine the effect of variations in the concentration of SLS and NaCl on the physical and chemical properties of shampoo. This research is an experimental study with 8 formulas. Includes organoleptic test, homogeneity test, viscosity test, foam height test, specific gravity test, and pH test. Making shampoo preparations by weighing all ingredients according to each formulation, leaving the shampoo for 1 day before testing for 4 weeks of storage.</em><em>The results showed that the organoleptic test and the homogeneity test of NaCl and SLS had no effect on shampoo. In the specific gravity test and the pH test of NaCl and SLS there was no dominant influence on the specific gravity of shampoo. In the foam height test, the SLS coefficient value is higher than NaCl so that SLS dominantly affects the height of the shampoo foam. In the viscosity test the coefficient value of NaCl is higher than SLS so that NaCl dominantly affects the viscosity of the shampoo. The conclusion from this research is that NaCl has a dominant influence on the physical properties, namely viscosity, while SLS has a dominant influence on the physical properties, namely the height of the shampoo foam.</em></p> Luh Nela Andriani I Gusti NAWW Putra I Ketut Tunas ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 366 384 10.33759/jrki.v4i3.304 STUDI TINGKAT PENGETAHUAN DAN PERILAKU SWAMEDIKASI OBAT ANALGESIK PADA PASIEN DI APOTEK KOTA SAMARINDA http://jurnalfarmasi.or.id/index.php/jrki/article/view/298 <p><em>Self-medication is a behavior of the community to perform health treatment for themselves without having to consult with health workers. Analgesic is a non-steroidal anti-inflammatory drug (NSAID) group that is used to relieve pain, so it is often used by people to treat pain without losing awareness. This study aimed to describe the study of the level of knowledge and behavior of self-medication of analgesic drugs at the Samarinda City Pharmacy. This research is a type of quantitative research with the cross-sectional method. Sampling using non-probability sampling by purposive sampling. The sample used in this study was 147 respondents. The results showed that the majority of respondents on drug selection indicators (89.1%), drug class (83.65%), how to use (92.5%), and drug storage (75.96%) with behavioral levels on the selection indicator. drug (89.8%), drug class (87.1%), method of use (83.7%), and drug storage (77.5%). The patient's level of knowledge and the behavior of self-medication of analgesic drugs is included in the good category.</em></p> Aprilia Diah Susanti Sinta Ratna Dewi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 385 396 10.33759/jrki.v4i3.298 PERILAKU PENGGUNAAN ANTIBIOTIK TANPA RESEP DI APOTEK X DI KOTA PAYAKUMBUH SUMATERA BARAT http://jurnalfarmasi.or.id/index.php/jrki/article/view/264 <p><em>Antibiotic are organic compounds produced by various species of microorganisms and are toxic to other species of microorganisms. Irrational use of antibiotic</em> <em>can lead to resistance. The problem of resistance in addition to having an impact on morbidity and morality also has a very high economic and social impact. Research has been done on the behavior of using antibiotic without a prescription at pharmacy x in Payakumbuh City. The purpose of this study was to determine the use of antibiotic without a doctor's prescription at pharmacy X in Payakumbuh City. This research is non-experimental with data analyzed included the level of awareness of the use of antibiotic. The study used a descriptive method with random or accidental</em><em> sampling with data </em><em>collection using a questionnaire with 100 samples from 5296 populations. The results showed that the most widely used antibiotics were amoxicillin (46%); the type of disease that most patients treated with antibiotics was toothache (33%); the most sources of information about antibiotics came from friends or family (35%); the reason most people use antibiotics without a doctor's prescription is that previous treatment has a satisfactory effect (36%) and the level of patient awareness of the use of antibiotics is still in the sufficient category (42%).</em></p> Mega Yulia Ruddy Parsono Khairil Armal ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 397 413 10.33759/jrki.v4i3.264 UJI RESISTENSI BAKTERI Escherichia coli DARI SUMBER AIR BAKU DI KARAWANG TERHADAP ANTIBIOTIK SIPROFLOKSASIN http://jurnalfarmasi.or.id/index.php/jrki/article/view/281 <p><em>Infectious diseases are included in the ten most common diseases in Indonesia. The disease can be overcome by the use of antimicrobials, one of which is antibiotics. Antibiotics are drugs used to treat infections caused by bacteria. Excessive use of antibiotics without clear indications can have an impact on the occurrence of bacterial resistance to these antibiotics. One of the bacteria that is resistant to antibiotics is Escherichia coli. This study aims to determine the sensitivity of Escherichia coli isolated from raw water sources in Karawang to the antibiotic ciprofloxacin. Samples were obtained from irrigation water which is the source of raw water for one branch of Perumdam in Karawang. The samples were tested using Lactose Broth (LB) media, then confirmed using Eosin Methylene Blue (EMBA) media to confirm the presence of Escherichia coli bacteria equipped with Gram stain. Bacterial resistance test was carried out using Mueller Hinton Agar (MHA) media with disc diffusion method. The results showed that the average diameter of the clear zone formed around the paper disc was 30.16 mm. The isolates showed intermediate results against the antibiotic ciprofloxacin.</em></p> Fuji Ayu Diniarti Ahsanal Kasasiah Indah Laily Hilmi ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-30 2022-09-30 4 3 414 429 10.33759/jrki.v4i3.281