Jurnal Riset Kefarmasian Indonesia

IDENTIFIKASI SENYAWA ANTIOKSIDAN DARI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius) DENGAN METODE 2,2-DIPHENYL-1-PICRYL-HYDRAZYL ( DPPH )

2023-06-01T01:51:54+00:00

Pandan wangi (Pandanus amaryllifolius) is one type of monocotyledonous in the Pandanaceae family that has leaves with a characteristic fragrant aroma. There is a chemical content in the leaves of pandan wangi (Pandanus amaryllifolius) namely alkaloids, flavonoids, saponins, tannins, and polyphenols that can be used as natural antioxidants. This study aims to identify the presence of antioxidant compounds in ethanol extract of pandan wangi leaves (Pandanus amaryllifolius). The research method is an experimental method. The extraction process by maceration and antioxidant testing of pandan wangi leaves (Pandanus amaryllifolius) ethanol extract used the DPPH method where Vitamin C being a positive control, and IC50 value as a parameter. The results stated that ethanol extract of Pandan wangi leaves (Pandanus amaryllifolius) has antioxidant activities that are classified as effective with an IC₅₀value of 27.65 ppm, while Vitamin C as positive control is classified as an effective antioxidant with an IC₅₀ value of 2.58 ppm. Based on the results of the research that has been done, it can be concluded that the ethanol extract of Pandan Wangi leaves has a good antioxidant content in counteracting free radicals.

EFEK LARVASIDA EKSTRAK ETANOL DAUN BINTANGUR (Chalophyllum inophyllum L.) TERHADAP MORTALITAS LARVA NYAMUK AIR KOTOR (Culex sp.)

2023-06-03T06:54:41+00:00

The Bintangur plant is a plant that can often be found around the house, its existence as a plant makes its properties less known to the public, all parts of this plant are known to be very useful for various pharmacological effects. Various efforts to prevent diseases transmitted by Culex sp. one of them uses larvicides, so an alternative larvicide from natural ingredients is needed, namely Bintangur. The purpose of this study was to determine the activity of the ethanol extract of Bintangur leaves in killing Culex sp larvae with the control being the larvae that were not given the ethanol extract of Bintangur leaves. The type of research on the activity test of the Bintangur leaf ethanol extract used an experimental research type with a true experiment design with a posttest only control group design. The results showed that the ethanol extract of Bintangur leaves (Chalophyllum Inophyllum L.) was active in killing Culex sp. larvae. with the results of the Reed and Muench test with an LC50 value of 281.84 ppm

UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR MINYAK ATSIRI KULIT BUAH JERUK BALI (Citrus maxima)

2023-06-01T01:04:58+00:00

Pomelofruit (Citrus maxima) has several chemical compounds, one of which is essential oil, 6.68g of essential oil was found in the peel of the pomelofruit (Citrus maxima) which has an active compound, namely limonene (94.96%). The essential oil provided strong antibacterial activity against S. aureus isolates. The purpose of the study was to formulate the essential oil of pomelofruit peel (Citrus maxima) into liquid soap preparations that met physical stability and to test the antibacterial activity of liquid soap preparations of pomelofruit (Citrus maxima) peel essential oil against S. aureus bacteria. The method used in testing the stability of liquid soap preparations is cycling test and in the antibacterial activity test using the Disk diffusion method. The results obtained that the essential oil of pomelofruit peel (Citrus maxima) can be formulated in the form of liquid soap because it meets the physical stability test, namely before and after the cycling test and activity tests. antibacterial against S. aureus. at 1% concentration of 18.9mm (strong), 3% of 20.4mm (very strong), and 5% of 21.1mm (very strong). Based on this, the essential oil of pomelofruit peel (Citrus maxima) can be made into liquid soap preparations that meet the physical stability test and have antibacterial activity in very strong category at a concentration of 5% in inhibiting the growth of S. aureus bacteria.

FORMULASI SEDIAAN SPRAY GEL EKSTRAK DAUN BANDOTAN (Ageratum conyzoides.L) SEBAGAI ANTINYAMUK

2023-06-01T01:04:58+00:00

There are many types of mosquitoes that cause disease in humans, one of which is the Anopheles mosquito that spreads malaria. Bandotan plants are used to treat colic, flu, fever, antidiarrheal, diarrhoea. The purpose of this study was to determine the concentration of bandotan (Ageratum conyzoides.L) leaf extract that provides the best physical properties and anti-mosquito activity in spray gel preparations. The research method conducted was experimental. The object studied was the formulation of bandotan leaf preparation as an antinyamite. The research stages include plant determination, sample collection, simplisia preparation, extraction using maceration method with 70% ethanol solvent, identification of secondary metabolite compounds, preparation of spray gel formula, and preparation evaluation. Bandotan leaf extract was formulated into anti-mosquito spray gel preparations with concentration variants of 10%, 15%, 20%, and using positive control of X brand anti-mosquito spray as a comparison. The preparation testing included organoleptic test, homogeneity test, pH test, viscosity test, and mosquito repellency test. The results of data collection were analysed statistically. A good preparation formula is found in the negative control formula because it has a stable consistency and pH. The results showed that the ethanol extract of bandotan leaves was not significantly different from the organoleptic test, homogeneity test, viscosity test, and pH test. The greatest mosquito repellency was at a concentration of 20% which was 66.33%, at concentrations of 10% and 15% had an average anti-mosquito activity of 22.83% and 57.83% respectively for the positive control with brand X of 99.30%.

IDENTIFIKASI JENIS SAPONIN DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL KULIT BATANG SEKILANG (Embelia borneensis Scheff.) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 9027 DAN Streptococcus mutans ATCC 25175

2023-06-01T01:04:58+00:00

Sekilang stem bark (Embelia borneensis Scheff.) contains secondary metabolites, such as alkaloids, flavonoids, tannins, and saponins. Saponin compounds are divided into two types, namely steroids and triterpenoids which have the ability as antibacterial, antifungal, antidiabetic and expectorant. The purpose of this study was to determine the type of saponin and to determine the antibacterial activity of the methanolic extract of sekilang bark against Streptococcus mutans and Pseudomonas aeruginosa bacteria. The research stages included plant determination, sample collection, simplicia making, extract preparation by maceration method using methanol, phytochemical screening, identification of saponins and antibacterial activity test of methanol extract of sekilang stem bark by disc diffusion method against Streptococcus mutans and Pseudomonas aeruginosa bacteria with a concentration of 15% , 20%, 25%, 30%, and 35%. The results showed that the methanol extract of sekilang stem bark contained triterpenoid saponins and had antibacterial activity against Streptococcus mutans bacteria at concentrations of 15%, 20%, 25%, 30%, and 35% with an inhibition zone formed of 7.65 mm, 7.89 mm, 7.67 mm, 7.98 mm, and 7.13 mm the criteria for antibacterial strength were categorized as moderate. The methanolic extract of the bark of sekilang did not show antibacterial activity against Pseudomonas aeruginosa bacteria, because there was no inhibition zone formed around the paper disc. The positive control used was amoxicillin 0.1% and the negative control used 1% DMSO.

POTENSI ANTIBAKTERI EKSTRAK ETANOL DAUN SELUTUI PUKA (Tabernaemontana macrocarpa Jack.) TERHADAP BAKTERI Streptococcus mutans DAN Porphyromonas gingivalis

2023-06-01T01:04:58+00:00

The Dayak people in West Kutai, East Kalimantan use selutui puka leaves for the treatment of toothache and canker sores. Bacteria that often cause infections in the oral cavity are Streptococcus mutans and Porphyromonas gingivalis. The aim of this study was to determine the activity of the ethanol extract of selutui puka leaves as an antibacterial against Streptococcus mutans and Porphyromonas gingivalis. The research phase involved collecting samples, plant determination, preparing simplicia, preparing extracts and testing antibacterial activity using the paper disc diffusion method with extract concentrations of 15%, 30% and 45%, DMSO negative control 1%, positive control Ciprofloxacin 0.1%. The results showed that the average diameter of the inhibition zone for Streptococcus mutans at an extract concentration of 15% was 17.70 mm (strong), 30% was 19.43 mm (strong), and 45% was 23.60 mm (very strong). ) and against Porphyromonas gingivalis bacteria at an extract concentration of 15% of 17.43 mm (strong), 30% of 23.33 mm (very strong), and 45% of 26.03 mm (very strong).

UJI ANTIOKSIDAN EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) LERENG GUNUNG ARGOPURA KABUPATEN JEMBER PADA BERBAGAI KONDISI PENYANGRAIAN

2023-06-01T01:04:58+00:00

Coffee (Coffea arabica L.) is a plant which has been cultivated in Indonesia and it is one of natural source of antioxidants. The main bioactive component which contain antioxidant properties is chlorogenic acid. The roasting process can cause chlorogenic acid in coffee beans to decrease as the temperature increases and the length of roasting, so the way coffee is served as a source of antioxidants which may need to be considered. The purpose of this study was to determine the group of compounds and antioxidant activity contained in Arabica coffee beans obtained from the slopes of Mount Argopura at various conditions of roasting. The samples of Arabica coffee beans each done roasting in advance at a temperature of 160°C - 180°C; 190°C - 210°C; and 220°C - 240°C before it is milled. The used of extraction method is maceration using 80% ethanol solvent. Antioxidant activity testing was done by DPPH method. Antioxidant activity is expressed based on the IC₅₀ value (Inhibitor Concentration 50%). The highest value of antioxidant activity was obtained from Arabica coffee beans roasted at a moderate temperature with a value of IC₅₀ 26.41 ± 0.182 ppm. The result of the T-test obtained a sig value < 0.05 which indicates a difference in the antioxidant activity produced by the extract of Arabica coffee beans at various conditions of roasting.

ANALISIS RESEP TIDAK TERLAYANI PASIEN RAWAT JALAN DI INSTALASI FARMASI RSU X JAKARTA

2023-06-01T01:04:59+00:00

Pharmacy service is inseparable from health service system of a hospital. The service of pharmacy unit shall be a priority because an effective and efficient service will affect in the fulfillment of prescriptions. Furthermore, the management on the pharmaceutical stock will influence the revenue of the hospital (part of revenue center). The purpose of this research is to find out the percentage of unfilled prescriptions of outpatients from many different units, its reasons, and Therapeutic Class of unserved drug items. The research applies descriptive method using prospective data i.e. 25,259 R/ sheets of prescriptions obtained by total sampling technique. The research was conducted in three months from February to April 2021. The result of the research shows that there are unfilled 467 R/ prescriptions due to several factors, such as the drugs are not listed in the formularies, the drugs are out of stock, and the prescribed or patient-requested drugs are not covered by the insurance. Internal medicine unit has the most unfilled prescriptions (160 out of 467). The main reason is the drugs are out of stock (133 out of 467). Medicines for Gastritic, Respiratory, Heart Diseases and Allergicare the top lists in the Therapeutic Class, which is in accordance with data showing that Intenal Medicine, Emergency Department dan General Practisioners, Pulmonary, Dermatology and Venereology, and Obstetrics and Gynecology are the top 5 polyclinics with the number of unserved prescriptions due to out of stock.

FORMULASI LIP BALM EKSTRAK LIDAH BUAYA (ALOE VERA) DAN BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI PELEMBAB BIBIR

2023-06-01T01:37:58+00:00

Lip balm is a cosmetic preparation with main components such as waxes, fats and oils. The purpose of this study was to determine whether Aloe vera and red dragon fruit extracts could be formulated as moisturizers and natural dyes in lip balm preparations. The study was carried out experimentally, including the formulation of preparations with concentrations of Aloe Vera extract 3%, 6%, 10%, and Red Dragon Fruit extract 3%, 5%, 7%. Examination of the physical quality of the preparation, namely homogeneity test, stability during 28 days of storage at room temperature, melting point, pH, and preference test. The results showed that (F1) with a concentration of 3% aloe vera and 3% red dragon fruit met the requirements for homogeneity, melting point, pH, and stability tests, on (F2) with a concentration of 6% aloe vera and 5% red dragon fruit does not meet the requirements of the pH test, but meets the requirements of the homogeneity test, melting point test, and stability test. Whereas for (F3) with a concentration of 10% aloe vera and 7% red dragon fruit did not meet the homogeneity and pH test requirements, but met the melting point and stability test requirements. It can be concluded that Aloe Vera Extract and Red Dragon Fruit can be formulated into lip balm dosage forms. Differences in concentration variations can affect the moisture on the skin and the color of the preparation.